Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

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• 作者：Priscila A. Costa ; Jefferson H. Z. Poli ; Nathalia D. M. Sperotto…
• 关键词：Ethanol ; Alcohol withdrawal ; Anxiety ; like ; Brain DNA damage ; ROS
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：232
• 期：19
• 页码：3623-3636
• 全文大小：843 KB
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• 作者单位：Priscila A. Costa (1)
  Jefferson H. Z. Poli (1)
  Nathalia D. M. Sperotto (2)
  Dinara J. Moura (2)
  Jenifer Saffi (2)
  Maur铆cio S. Nin (1) (3)
  Helena M. T. Barros (1) (4)
  
  1. Laboratory of Neuropsycopharmacology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil
  2. Laboratory of Toxicological Genetics, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil
  3. Department of Pharmacy, Discipline of Statistics, Methodist University of South-IPA, Porto Alegre, Brazil
  4. Department of Pharmacosciences, Federal University of Health Sciences of Porto Alegre, 245 Sarmento Leite Street, Laboratory 317, Porto Alegre, PC 90050-170, Brazil
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Alcohol addiction causes severe problems, and its deprivation may potentiate symptoms such as anxiety. Furthermore, ethanol is a neurotoxic agent that induces degeneration and the consequences underlying alcohol-mediated brain damage remain unclear.