Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery

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• 作者：Yves Denizot (1)
  Alexandre Leguyader (2)
  Elisabeth Cornu (2)
  Marc Laskar (2)
  Isabelle Orsel (3)
  Christelle Vincent (1)
  Nathalie Nathan (3)
  
• 刊名：Journal of Cardiothoracic Surgery
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：2
• 期：1
• 全文大小：497KB
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• 作者单位：Yves Denizot (1)
  Alexandre Leguyader (2)
  Elisabeth Cornu (2)
  Marc Laskar (2)
  Isabelle Orsel (3)
  Christelle Vincent (1)
  Nathalie Nathan (3)
  
  1. UMR CNRS 6101, Centre National de la Recherche Scientifique, Universit茅 de Limoges, France
  2. Service de Chirurgie Thoracique et Cardiovasculaire, CHU Dupuytren, Limoges, France
  3. Service d'Anesth茅sie R茅animation Chirurgicale, CHU Dupuytren, Limoges, France
  

文摘

Background This study was conducted to follow plasma concentrations of sFlt-1 and sKDR, two soluble forms of the vascular endothelial growth factor (VEGF) receptor in patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulation (ECC). Methods Plasma samples were obtained before, during and after surgery in 15 patients scheduled to undergo CABG. Levels of sFlt-1 and KDR levels were investigated using specific ELISA. Results A 75-fold increase of sFlt-1 was found during cardiac surgery, sFlt-1 levels returning to pre-operative values at the 6th post-operative hour. In contrast sKDR levels did not change during surgery. The ECC-derived sFlt-1 was functional as judge by its inhibitory effect on the VEGF mitogenic response in human umbilical vein endothelial cells (HUVECs). Kinetic experiments revealed sFlt-1 release immediately after the beginning of ECC suggesting a proteolysis of its membrane form (mFlt-1) rather than an elevated transcription/translation process. Flow cytometry analysis highlighted no effect of ECC on the shedding of mFlt-1 on platelets and leukocytes suggesting vascular endothelial cell as a putative cell source for the ECC-derived sFlt-1. Conclusion sFlt-1 is released during CABG with ECC. It might be suggested that sFlt-1 production, by neutralizing VEGF and/or by inactivating membrane-bound Flt-1 and KDR receptors, might play a role in the occurrence of post-CABG complication.