NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum

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• 作者：Francesca Boscia ; Antonella Casamassa ; Agnese Secondo…
• 关键词：Na/Ca+2 exchanger ; NCX1 ; Calretinin ; Preconditioning ; Tolerance ; Cerebral ischemia
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：53
• 期：2
• 页码：1365-1376
• 全文大小：1,676 KB
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• 作者单位：Francesca Boscia (1)
  Antonella Casamassa (1)
  Agnese Secondo (1)
  Alba Esposito (1)
  Anna Pannaccione (1)
  Rossana Sirabella (2)
  Giuseppe Pignataro (1)
  Ornella Cuomo (1)
  Antonio Vinciguerra (1)
  Valeria de Rosa (1)
  Lucio Annunziato (1) (2)
  
  1. Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy
  2. Fondazione IRCSS SDN, Naples, Italy
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Recently, the Na+/Ca+2 exchanger NCX1 and the calcium binding protein calretinin have emerged as new molecular effectors of delayed preconditioning in the brain. In the present study, we investigated whether NCX1 and calretinin cooperate within the preconditioned striatum to confer neurons greater resistance to degeneration. Confocal microscopy analysis revealed that NCX1 expression was upregulated in calretinin-positive interneurons in the rat striatum after tolerance induction. Consistently, coimmunoprecipitation assays performed on human SHSY-5Y cells, a neuronal cell line which constitutively expresses calretinin, revealed a binding between NCX1 and calretinin. Finally, silencing of calretinin expression, both in vitro and in vivo, significantly prevented preconditioning-induced neuroprotection. Interestingly, our biochemical and functional studies showed that the selective silencing of calretinin in brain cells significantly prevented not only the preconditioning-induced upregulation of NCX1 expression and activity but also the activation of the prosurvival protein kinase Akt, which is involved in calretinin and NCX1 protective actions. Collectively, our results indicate that the Na+/Ca+2 exchanger NCX1 and the calcium binding protein calretinin cooperate within the striatum to confer tolerance against cerebral ischemia. Keywords Na/Ca+2 exchanger NCX1 Calretinin Preconditioning Tolerance Cerebral ischemia