Prevalence of vertebral fractures and quality of life in a sample of postmenopausal Brazilian women with osteoporosis

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• 作者：Néville de Oliveira Ferreira (1)
  Raimunda Beserra da Silva (2)
  Michael Arthuso (3)
  Aar?o Mendes Pinto-Neto (4)
  Nelson Caserta (5)
  Lúcia Costa-Paiva (6)
  
• 关键词：Osteoporotic fractures ; Spinal fractures ; Prevalence study ; Epidemiology ; Postmenopausal osteoporosis
• 刊名：Archives of Osteoporosis
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：7
• 期：1-2
• 页码：101-106
• 全文大小：143KB
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  5. Siris ES, Brenneman SK, Barrett-Connor E, Miller PD, Sajjan S, Berger ML et al (2006) The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50 / -/em>99: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 17:565-74. doi:10.1007/s00198-005-0027-4 CrossRef
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  11. Cockerill W, Lunt M, Silman AJ, Cooper C, Lips P, Bhalia AK et al (2004) Health-related quality of life and radiographic vertebral fracture. Osteoporos Int 15:113-19. doi:10.1007/s00198-003-1547-4 CrossRef
  12. Oleksik AM, Ewing S, Shen W, van Schoor NM, Lips P (2005) Impact of incident vertebral fractures on health-related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporos Int 16:861-70. doi:10.1007/s00198-004-1774-3 CrossRef
  13. Adachi JD, Ioannidis G, Olszynski WP, Brown JP, Hanley DA, Sebaldt RJ et al (2002) The impact of incident vertebral and non-vertebral fractures on health related quality of life in post-menopausal women. BMC Musculoskel Disord 3:11. doi:10.1186/1471-2474-3-11 CrossRef
  14. Fechtenbaum J, Cropet C, Kolta S, Horlait S, Orcel P, Roux C et al (2005) The severity of vertebral fractures and health-related quality of life in osteoporotic postmenopausal women. Osteoporos Int 16:2175-179. doi:10.1007/s00198-005-2023-0 CrossRef
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  16. Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O, Kanis A et al (1999) Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int 10:150-60. doi:10.1007/s001980050210 CrossRef
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  19. de Oliveira FN, Arthuso M, da Silva R, Pedro AO, Neto AM, Costa-Paiva L (2009) Quality of life in women with postmenopausal osteoporosis: correlation between QUALEFFO 41 and SF-36. Maturitas 62:85-0. doi:10.1016/j.maturitas.2008.10.012 CrossRef
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  21. Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Jhonell O et al (1997) Quality of life as outcome in the treatment of osteoporosis: development of a questionnaire for quality of life by the European Foundation for Osteoporosis. Osteoporos Int 7:36-8. doi:10.1007/bf01623457 CrossRef
  22. McCloskey EV, Spector TD, Eyres KS et al (1993) The assessment of vertebral deformity: a method for use in population studies and clinical trials. Osteoporos Int 3:138-47. doi:10.1007/bf01623275 , doi:10.1590/S0482-50042010000200002 CrossRef
  23. Pinheiro MM, Ciconelli RM, Martini LA, Ferraz MB (2009) Clinical risk factors for osteoporotic fractures in Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS). Osteoporos Int 20(3):399-08. doi:10.1007/s00198-008-0680-5
  
• 作者单位：Néville de Oliveira Ferreira (1)
  Raimunda Beserra da Silva (2)
  Michael Arthuso (3)
  Aar?o Mendes Pinto-Neto (4)
  Nelson Caserta (5)
  Lúcia Costa-Paiva (6)
  
  1. Women’s Integrated Healthcare Center (CAISM), Universidade Estadual de Campinas (UNICAMP), Campinas, S?o Paulo, Brazil
  2. Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil
  3. School of Medicine, Universidade Estadual de Campinas (UNICAMP), Campinas, S?o Paulo, Brazil
  4. Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas (UNICAMP), Campinas, S?o Paulo, Brazil
  5. Department of Radiology, School of Medicine, Universidade Estadual de Campinas (UNICAMP), Campinas, S?o Paulo, Brazil
  6. Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas (UNICAMP), Rua Alexander Fleming, 101, Cidade Universitária, Campinas, S?o Paulo, 13083-330, Brazil
  

文摘

Summary The prevalence of vertebral fracture was high in postmenopausal Brazilian osteoporotic women; quality of life was impaired regardless of vertebral fractures, despite a direct correlation between the number of vertebral fractures and a worse quality of life score. Purpose The purpose of this study is to evaluate the prevalence of vertebral fractures (VF), quality of life (QOL), association between number of VF and QOL scores, and correlate the factors associated with QOL in a sample of postmenopausal Brazilian women with osteoporosis. Methods A cross-sectional study of 126 postmenopausal osteoporotic women aged 55-0?years was conducted. Women were interviewed about sociodemographic and clinical data, responded to QUALEFFO-41 questionnaire, and underwent vertebral radiography to measure the anterior, mean, and posterior height at each vertebra (T4 to L5). VF were classified as anterior wedge, posterior wedge, central collapse, and crush. Data was expressed as means (±SD) and frequencies, Mann–Whitney or Student’s T tests were used to compare means, and odds ratio and 95?% confidence interval were used for multiple regression analysis. Values were significant when P value-lt;-.05. Results The mean age was 65.7?±-.3?years, age at menopause was 46.5?±-.8?years and T score of the lumbar spine was ?.77?±-.58. The prevalence of VF was 34.1?% (43/126) and the most prevalent type of VF was anterior wedge (45.9?%). There was no difference in QUALEFFO-41 scores between women with and without VF, although there was a direct correlation between QOL scores and number of VF. Factors associated with worse QOL were non-white skin color, obesity, unemployment, sedentary lifestyle, low level of school education, and non-use of osteoporosis drugs. Conclusion There was a high prevalence of VF in Brazilian postmenopausal women with osteoporosis. QOL was impaired regardless of VF, despite a direct correlation between number of VF and a worse QOL score.