La gestion des néoplasies épithéliales de la surface oculaire de type épidermo?de

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• 作者：A. Chebbi ; H. Bouguila ; H. Lajmi ; O. Fekiih…
• 关键词：Néoplasies épithéliales de la surface de type épidermo?de ; Clinique ; Histopathologie ; Chirurgie ; Radiothérapie ; Ocular surface squamous neoplasia ; Clinical ; Histopathology ; Surgery ; Radiotherapy
• 刊名：Journal Africain du Cancer / African Journal of Cancer
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：7
• 期：1
• 页码：34-40
• 全文大小：409 KB
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• 刊物主题：Oncology; Tropical Medicine;
• 出版者：Springer Paris
• ISSN：1965-0825

文摘

Purpose The aim of this study was to report our experience in ocular surface squamous neoplasia management and to analyze the tumor recurrence risk factors. Materials and methods We included 69 patients having an ocular surface squamous neoplasia. All of them underwent a complete ophthalmological examination with a precise evaluation of the extension. The treatment was based on surgery, cryotherapy, topical chemotherapy, and brachytherapy. Results The mean age in our series was of 60.5 (±20.3) years with a sex-ratio of 2.28. The tumor was in the bulbar conjunctiva in 62 cases (89.8%) and in the tarsal conjunctiva in 7 cases (10%). The mean tumor size was of 12.3 mm. The histopathological analysis showed an invasive carcinoma in 51 cases (74%) and conjunctival intraepithelial neoplasia in 18 cases (26%). A locoregional extension was noted in 55 patients (69.6%). The tumor recurrence rate was 31.8%. The global survival rate was 93% at 3 years. Recurrence risk factors found in our study were the medial canthus location (P = 0.002), the tumoral size superior to 10 mm (P = 0.02), the sclera extension (P = 0.01), and the initial treatment (P = 0.03). There was no correlation with the anatomoclinical aspect (P = 0.6) and the corneal extension (P = 0.2). Conclusion The global survival rate of the ocular surface squamous neoplasia (OSSN) is excellent because of the low locoregional extension and distance rates. The main problem with these tumors is the high rate of recurrence.