Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis

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• 作者：Thomas H. Flynn (1) tomhflynn@gmail.com
  Bita Manzouri (1)
  Stephen J. Tuft (1)
• 关键词：Ocular surface squamous neoplasia – ; Ciclosporin – ; Atopic keratoconjunctivitis
• 刊名：International Ophthalmology
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：32
• 期：5
• 页码：471-473
• 全文大小：178.8 KB
• 参考文献：1. Heinz C, Fanihagh F, Steuhl KP (2003) Squamous cell carcinoma of the conjunctiva in patients with atopic eczema. Cornea 22(2):135–137
  2. Kallen C, Reinhard T, Schilgen G, Cartsburg O, Bocking A, Auw-Hadrich C et al (2003) Atopic keratoconjunctivitis: probably a risk factor for the development of conjuntival carcinoma. Ophthalmologe 100(10):808–814
  3. Rundle P, Mudhar HS, Rennie I (2010) Conjunctival intra-epithelial neoplasia occurring in young patients with asthma. Eye (London) 24(7):1182–1185
  4. Ulrich C, Kanitakis J, Stockfleth E, Euvrard S (2008) Skin cancer in organ transplant recipients—where do we stand today? Am J Transplant 8(11):2192–2198
  5. Yarosh DB, Pena AV, Nay SL, Canning MT, Brown DA (2005) Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol. 125(5):1020–1025
  6. Macarez R, Bossis S, Robinet A, Le Callonnec A, Charlin JF, Colin J (1999) Conjunctival epithelial neoplasias in organ transplant patients receiving cyclosporine therapy. Cornea 18(4):495–497
  7. Shelil AE, Shields CL, Shields JA, Eagle RC Jr (2003) Aggressive conjunctival squamous cell carcinoma in a patient following liver transplantation. Arch Ophthalmol 121(2):280–282
  8. Pournaras JA, Chamot L, Uffer S, Zografos L (2007) Conjunctival intraepithelial neoplasia in a patient treated with tacrolimus after liver transplantation. Cornea 26(10):1261–1262
  9. Rustin MH (2007) The safety of tacrolimus ointment for the treatment of atopic dermatitis: a review. Br J Dermatol 157(5):861–873
  10. Bohringer D, Wojanowski B, Reinhard T (2008) Prolonged exposure to topical cyclosporine A does not seem to promote conjunctival malignancy. Acta Ophthalmol 86(4):462
• 作者单位：1. Moorfields Eye Hospital, City Road, London, EC1V 2PD UK
• ISSN：1573-2630

文摘

We describe a patient with severe atopic dermatitis and keratoconjunctivitis, who was prescribed both systemic and topical ciclosporin and who developed ocular surface squamous neoplasia (OSSN). To provide additional information on the incidence of the association between topical ciclosporin use and OSSN, we counted the total prescriptions for topical ciclosporin issued in our hospital between 2003 and 2006 (804 patients) and, for the same period, we reviewed the records of patients with OSSN for a history of treatment with ciclosporin or a history of atopy. No other case of OSSN in a patient with a history of topical ciclosporin use was identified, which makes it difficult to implicate topical ciclosporin as the causative factor.