Use of diagnostic dynamic contrast-enhanced (DCE)-MRI for targeting of soft tissue tumour biopsies at 3T: preliminary results

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• 作者：Iris-Melanie Noebauer-Huhmann ; Gabriele Amann ; Martin Krssak…
• 关键词：Neoplasms ; connective and soft tissue ; Image ; guided biopsy ; MR ; guided interventional procedures ; 3Tesla MRI ; Dynamic contrast enhancement ; DCE
• 刊名：European Radiology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：25
• 期：7
• 页码：2041-2048
• 全文大小：779 KB
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  11.van Rijswijk CS, Geirnaerdt MJ, Hogendoorn PC et al (2004) Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy. Radiology 233:493-02PubMed View Article
  12.van Rijswijk CS, Kunz P, Hogendoorn PC, Taminiau AH, Doornbos J, Bloem JL (2002) Diffusion-weighted MRI in the characterization of soft-tissue tumors. J Magn Reson Imaging 15:302-07PubMed View Article
  13.Fayad LM, Barker PB, Jacobs MA et al (2007) Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy. AJR Am J Roentgenol 188:1513-520PubMed View Article
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  16.Wang CK, Li CW, Hsieh TJ, Chien SH, Liu GC, Tsai KB (2004) Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy: initial results. Radiology 232:599-05PubMed View Article
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• 作者单位：Iris-Melanie Noebauer-Huhmann (1) (10) (2)
  Gabriele Amann (3)
  Martin Krssak (2) (4)
  Joannis Panotopoulos (5)
  Pavol Szomolanyi (2) (6)
  Michael Weber (1)
  Christian Czerny (1)
  Martin Breitenseher (7)
  Guenther Grabner (2)
  Wolfgang Bogner (2)
  Stefan Nemec (1)
  Martin Dominkus (8)
  Philipp Funovics (5)
  Reinhard Windhager (5)
  Siegfried Trattnig (2) (9)
  
  1. Department of Biomedical Imaging and Image-guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria
  10. Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna/Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria
  2. High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
  3. Clinical Institute for Pathology, Medical University of Vienna, Vienna, Austria
  4. Department of Internal Medicine III, Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
  5. Department of Orthopaedics, Medical University of Vienna, Vienna, Austria
  6. Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
  7. Landesklinikum Waldviertel Horn, Horn, Austria
  8. Orthopaedics Hospital Speising, Vienna, Austria
  9. Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives To test the feasibility and accuracy of MR-guided soft tissue tumour biopsy at 3T, using the dynamic contrast-enhanced (DCE) information from staging MRI for intralesional targeting. Methods After obtaining written informed consent for this institutional review board-approved study, 53 patients with suspected soft tissue tumours prospectively underwent preoperative staging MRI at 3T, including DCE, and subsequent MR-guided core needle biopsy. In 44/53 cases, DCE was heterogeneous and was used for intralesional biopsy targeting. Surgical, whole-specimen histology was used as the gold standard in 43/44 patients and revealed 42 soft tissue tumours (24 men; 18 women; mean age, 52?years; range, 19 -84). Results Final surgical histology revealed eight benign lesions, six tumours of intermediate dignity, and 28 malignancies. All malignancies had shown heterogeneous DCE. The diagnostic yield of the biopsies was 100?% (42/42). Histological accuracy rates of biopsy were 100?% in predicting the dignity (42/42; 95?% CI [0.916 -1.000]), 95.2?% for the tissue-specific entity (40/42; 95?% CI [0.847 -0.987]), and 90.5?% for the tumour grade (38/42; 95?% CI [0.779 -0.962]). Conclusions Our preliminary study indicates that biopsy of soft tissue tumours can be performed accurately and safely with DCE targeted MR-guidance at 3T, using a combined staging/biopsy MRI protocol. Key Points -MR-guided soft tissue tumour biopsy using DCE for intralesional targeting is feasible. -Targeting by staging-MRI allows reliable planning of the biopsy approach. -The method seems accurate and safe as a combined staging/biopsy procedure in outpatients. -DCE-targeted biopsy seems useful in challenging large and heterogeneous tumours.