Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines

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• 作者：Jingting Mai ; Fei Wang ; Qiong Qiu ; Buzhou Tang ; YongQing Lin…
• 关键词：Tachycardia pacing ; Non ; ischemic heart failure ; Neovascularization ; Endothelial progenitor cells
• 刊名：Heart and Vessels
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：31
• 期：2
• 页码：230-240
• 全文大小：6,435 KB
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• 作者单位：Jingting Mai (1) (2)
  Fei Wang (3)
  Qiong Qiu (1) (2)
  Buzhou Tang (4)
  YongQing Lin (1) (2)
  NianSang Luo (1) (2)
  WoLiang Yuan (1) (2)
  XiaoLong Wang (4)
  Qingcai Chen (4)
  JingFeng Wang (1) (2)
  YangXin Chen (1) (2)
  
  1. Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China
  2. Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, 510120, China
  3. Department of Anesthesiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China
  4. Intelligent Computing Research Center, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, 518055, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  Biomedical Engineering
  Interventional Radiology
  Ultrasound
  
• 出版者：Springer Japan
• ISSN：1615-2573

文摘

Neovascularization plays pivotal role in ischemic heart failure; however, it is unclear in non-ischemic heart failure. Non-ischemic heart failure was induced by chronic rapid right ventricular pacing at 200 beats/min, respectively, for 3 and 6 weeks in 12 dogs. Sham-operation was performed in another 6 dogs as control. Three-week tachycardia pacing could induce mild/moderate heart failure and 6-week pacing could induce severe heart failure. Pan-microvessel density (MVD) was assessed by CD31 and neovascularization density was assessed by CD105. Mean CD31-MVD and CD105-MVD were significantly increased after 3-week pacing. However, CD105-MVD was significantly decreased by 80 % in 6-week pacing group compared with 3-week pacing group, whereas CD31-MVD was only decreased slightly (15 %; P < 0.05). Myocardial proangiogenic factor stromal cell-derived factor 1 (SDF-1), hypoxia-inducible factors 1α (HIF-1α, a transcription factor which could regulate SDF-1 expression), serum SDF-1 levels and circulating EPC mobilization were greatly elevated after 3-week pacing but nearly returned to baseline level after 6-week pacing, which were in accordance with the changes of neovascularization levels assessed by CD105. Angiogenesis and migrating ability of EPCs were enhanced after stimulation of SDF-1, which could be abolished by pretreatment with SDF-1 receptor antagonist AMD3100. In addition, angiogenesis and migrating functions of EPCs were significantly enhanced by the serum from 3-week pacing dogs, but had much weaker response to the serum from 6-week pacing dogs. In conclusion, tachycardia pacing-induced non-ischemic heart failure, promoted myocardial neovascularization and mobilized circulating EPCs, which might be mediated partly through SDF-1 pathway. Keywords Tachycardia pacing Non-ischemic heart failure Neovascularization Endothelial progenitor cells