Are Sleep Disturbances Preclinical Markers of Parkinson’s Disease?

详细信息    查看全文

• 作者：Altair B. dos Santos ; Kristi A. Kohlmeier ; George E. Barreto
• 关键词：Parkinson’s disease ; Sleep disturbances ; Non ; motor signs ; Preclinical markers
• 刊名：Neurochemical Research
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：40
• 期：3
• 页码：421-427
• 全文大小：164 KB
• 参考文献：1. Friedman, JH, Millman, RP (2008) Sleep disturbances and Parkinson’s disease. CNS Spectr 13: pp. 12-17
  2. Aarsland, D, Zaccai, J, Brayne, C (2005) A systematic review of prevalence studies of dementia in Parkinson’s disease. Mov Disord 20: pp. 1255-1263 CrossRef
  3. Chaudhuri, KR, Healy, DG, Schapira, AH (2006) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5: pp. 235-245 CrossRef
  4. Lau, LM, Giesbergen, PC, Rijk, MC, Hofman, A, Koudstaal, PJ, Breteler, MM (2004) Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam study. Neurology 63: pp. 1240-1244 CrossRef
  5. Driver, JA, Logroscino, G, Gaziano, JM, Kurth, T (2009) Incidence and remaining lifetime risk of Parkinson disease in advanced age. Neurology 72: pp. 432-438 CrossRef
  6. Schenck, CH, Bundlie, SR, Mahowald, MW (1996) Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 46: pp. 388-393 CrossRef
  7. Chase, MH (2013) Motor control during sleep and wakefulness: clarifying controversies and resolving paradoxes. Sleep Med Rev 17: pp. 299-312 CrossRef
  8. Iranzo, A, Aparicio, J (2009) A lesson from anatomy: focal brain lesions causing REM sleep behavior disorder. Sleep Med 10: pp. 9-12 CrossRef
  9. Schenck, CH, Mahowald, MW (2002) REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in sleep. Sleep 25: pp. 120-138
  10. Postuma, RB, Gagnon, JF, Montplaisir, JY (2012) REM sleep behavior disorder: from dreams to neurodegeneration. Neurobiol Dis 46: pp. 553-558 CrossRef
  11. Fantini, ML, Farini, E, Ortelli, P, Zucconi, M, Manconi, M, Cappa, S, Ferini-Strambi, L (2011) Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep 34: pp. 619-625
  12. Postuma, RB, Gagnon, JF, Vendette, M, Montplaisir, JY (2009) Idiopathic REM sleep behavior disorder in the transition to degenerative disease. Mov Disord 24: pp. 2225-2232 CrossRef
  13. Schenck, CH, Bundlie, SR, Mahowald, MW (2003) REM behavior disorder (RBD): delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the minimum and maximum tonic and/or phasic electromyographic abnormalities found during REM sleep. Sleep 26: pp. A316
  14. Tippmann-Peikert, M, Olson, EJ, Boeve, BF, Silber, MH (2006) Idiopathic REM sleep behavior disorder: a follow-up of 39 patients. Sleep 29: pp. A272
  15. Sixel-Doring, F, Trautmann, E, Mollenhauer, B, Trenkwalder, C (2014) Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease?. Sleep 37: pp. 431-438
  16. Pal, PK, Calne, S, Samii, A, Fleming, JA (1999) A review of normal sleep and its disturbances in Parkinson’s disease. Parkinsonism Relat Disord 5: pp. 1-17 CrossRef
  17. Arnulf, I, Leu, S, Oudiette, D (2008) Abnormal sleep and sleepiness in Parkinson’s disease. Curr Opin Neurol 21: pp. 472-477 CrossRef
  18. Brito dos Santos, A, Campos, S, Ribeiro, S, Morales, L, Gonzalez, J, Trindade, J, Barreto, G (2013) Rela??o entre qualidade do sono e fun??es cognitivas em pacientes com doen?a de Parkinson. Univ Sci 18: pp. 269-281
  19. Menza, MA, Rosen, RC (1995) Sleep in Parkinson’s disease. The role of depression and anxiety. Psychosomatics 36: pp. 262-266 CrossRef
  20.
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

Parkinson’s disease (PD) is a neurobehavioral disorder characterized by motor symptoms and signs, and non-motor abnormalities such as olfactory dysfunction, pain, sleep disorders and cognitive impairment. Amongst these alterations, sleep disturbances play an important role in the pathology, but presence of disturbed sleep is not currently considered in diagnosis. However, sleeping problems may precede by many years the classic motor abnormalities of PD and should be clinically evaluated as a potential marker before disease onset. The first disturbance reported with this potential was the disorder REM sleep behaviour and currently several other disturbances have gained importance as potential markers, such as excessive daytime sleepiness, restless legs syndrome and new evidence also points to changes in circadian rhythms. Here we present a brief review of the major evidence indicating that sleep disturbances precede the motor symptoms in PD and neurodegeneration occurs in regions that could underlie these phenomena in order to provide support for the conclusion that disturbances of sleep should be considered as valuable preclinical markers for PD.