What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults?
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  • 作者:Eileen M. Moore ; Edward P. Riley
  • 关键词:Fetal alcohol spectrum disorders ; Adult ; Health ; Cognition ; Behavior
  • 刊名:Current Developmental Disorders Reports
  • 出版年:2015
  • 出版时间:September 2015
  • 年:2015
  • 卷:2
  • 期:3
  • 页码:219-227
  • 全文大小:313KB
  • 参考文献:Papers of particular interest, published recently, have been highlighted as: 鈥?Of importance1.Chudley AE, Conry J, Cook JL, Loock C, Rosales T, LeBlanc N. Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. CanMed Assoc J. 2005;172(5):S1鈥揝21.CrossRef
    2.Bertrand J, Floyd LL, Weber MK. Guidelines for identifying and referring persons with fetal alcohol syndrome. Morbid Mortal Wkly Rep Recomm Rep / Cent Dis Ctrl. 2005;54(11):1鈥?4.
    3.Astley SJ, Clarren SK. Diagnosing the full spectrum of fetal alcohol-exposed individuals: introducing the 4-digit diagnostic code. Alcohol Alcohol. 2000;35(4):400鈥?0.PubMed CrossRef
    4.Astley SJ. Validation of the fetal alcohol spectrum disorder (FASD) 4-Digit Diagnostic Code. J Popul Ther Clin Pharmacol. 2013;20(3):e416鈥?7.PubMed
    5.Hoyme HE, May PA, Kalberg WO, Kodituwakku P, Gossage JP, Trujillo PM, et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria. Pediatrics. 2005;115(1):39鈥?7.PubMed
    6.Streissguth AP, Aase JM, Clarren SK, Randels SP, LaDue RA, Smith DF. Fetal alcohol syndrome in adolescents and adults. JAMA. 1991;265(15):1961鈥?.PubMed CrossRef
    7.Spohr HL, Willms J, Steinhausen HC. Fetal alcohol spectrum disorders in young adulthood. J Pediatr. 2007;150(2):175鈥?. 9 e1.PubMed CrossRef
    8.Chudley AE, Kilgour AR, Cranston M, Edwards M. Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. Am J Med Genet C: Semin Med Genet. 2007;145C(3):261鈥?2.CrossRef
    9.Temple VK, Ives J, Lindsay A. Diagnosing FASD in adults: the development and operation of an adult FASD clinic in Ontario, Canada. J Popul Ther Clin Pharmacol. 2015;22(1):e96鈥?05.PubMed
    10.Mattson SN, Crocker N, Nguyen TT. Fetal alcohol spectrum disorders: neuropsychological and behavioral features. Neuropsychol Rev. 2011;21(2):81鈥?01.PubMed Central PubMed CrossRef
    11.Day NL, Helsel A, Sonon K, Goldschmidt L. The association between prenatal alcohol exposure and behavior at 22聽years of age. Alcohol Clin Exp Res. 2013;37(7):1171鈥?.PubMed CrossRef
    12.Connor PD, Sampson PD, Streissguth AP, Bookstein FL, Barr HM. Effects of prenatal alcohol exposure on fine motor coordination and balance: a study of two adult samples. Neuropsychologia. 2006;44(5):744鈥?1.PubMed CrossRef
    13.Connor PD, Streissguth AP, Sampson PD, Bookstein FL, Barr HM. Individual differences in auditory and visual attention among fetal alcohol-affected adults. Alcohol Clin Exp Res. 1999;23(8):1395鈥?02.PubMed CrossRef
    14.Coles CD, Lynch ME, Kable JA, Johnson KC, Goldstein FC. Verbal and nonverbal memory in adults prenatally exposed to alcohol. Alcohol Clin Exp Res. 2010;34(5):897鈥?06.PubMed Central PubMed CrossRef
    15.鈥?/div>Rangmar J, Sandberg AD, Aronson M, Fahlke C. Nord J Psychiatry. 2015:1鈥?. 2015.1009487. Adults with FAS have poorer short-term memory, working memory, planning ability, theory of mind, and a reduced sense of coherence compared to adult controls.
    16.Kodituwakku PW, Handmaker NS, Cutler SK, Weathersby EK, Handmaker SD. Specific impairments in self-regulation in children exposed to alcohol prenatally. Alcohol Clin Exp Res. 1995;19(6):1558鈥?4.PubMed CrossRef
    17.Streissguth AP, Bookstein FL, Barr HM, Sampson PD, O鈥橫alley K, Young JK. Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. J Dev Behav Pediatr. 2004;25(4):228鈥?8.PubMed CrossRef
    18.Famy C, Streissguth AP, Unis AS. Mental illness in adults with fetal alcohol syndrome or fetal alcohol effects. Am J Psychiatry. 1998;155(4):552鈥?.PubMed CrossRef
    19.Barr HM, Bookstein FL, O鈥橫alley KD, Connor PD, Huggins JE, Streissguth AP. Binge drinking during pregnancy as a predictor of psychiatric disorders on the Structured Clinical Interview for DSM-IV in young adult offspring. Am J Psychiatry. 2006;163(6):1061鈥?.PubMed CrossRef
    20.Streissguth A, Barr H, Kogan J, Bookstein F. Understanding the occurrence of secondary disabilities in clients with fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE). Final report to the Centers for Disease Control and Prevention (CDC). 1996;96鈥?6.
    21.Clark E, Lutke J, Minnes P, Ouellette-Kuntz H. Secondary disabilities among adults with fetal alcohol spectrum disorder in British Columbia. J FAS Int. 2004;2(e13):1鈥?2.
    22.Temple V, Shewfelt L, Tao L, Casati J, Klevnick L, Place S. Comparing daily living skills in adults with fetal alcohol spectrum disorders (FASD) to and IQ matched clinical sample. J Popul Ther Clin Pharmacol. 2011;18(2):e397鈥?02.
    23.鈥?/div>Rangmar J, Hjern A, Vinnerljung B, Stromland K, Aronson M, Fahlke C. Psychosocial outcomes of fetal alcohol syndrome in adulthood. Pediatrics. 2015;135(1):e52鈥?. Data from the National Registry in Sweden indicates that adults with FAS have more difficulties associated with secondary disorders than do adults in the general population.PubMed CrossRef
    24.Lebel C, Roussotte F, Sowell ER. Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain. Neuropsychol Rev. 2011;21(2):102鈥?8.PubMed Central PubMed CrossRef
    25.Chen X, Coles CD, Lynch ME, Hu X. Understanding specific effects of prenatal alcohol exposure on brain structure in young adults. Hum Brain Mapp. 2012;33(7):1663鈥?6.PubMed Central PubMed CrossRef
    26.Wozniak JR, Muetzel RL. What does diffusion tensor imaging reveal about the brain and cognition in fetal alcohol spectrum disorders? Neuropsychol Rev. 2011;21(2):133鈥?7.PubMed CrossRef
    27.Ma X, Coles CD, Lynch ME, LaConte SM, Zurkiya O, Wang D, et al. Evaluation of corpus callosum anisotropy in young adults with fetal alcohol syndrome according to diffusion tensor imaging. Alcohol Clin Exp Res. 2005;29(7):1214鈥?2.PubMed CrossRef
    28.Li L, Coles CD, Lynch ME, Hu X. Voxelwise and skeleton-based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults. Hum Brain Mapp. 2009;30(10):3265鈥?4.PubMed Central PubMed CrossRef
    29.Santhanam P, Li Z, Hu X, Lynch ME, Coles CD. Effects of prenatal alcohol exposure on brain activation during an arithmetic task: an fMRI study. Alcohol Clin Exp Res. 2009;33(11):1901鈥?.PubMed Central PubMed CrossRef
    30.Santhanam P, Coles CD, Li Z, Li L, Lynch ME, Hu X. Default mode network dysfunction in adults with prenatal alcohol exposure. Psychiatry Res. 2011;194(3):354鈥?2.PubMed Central PubMed CrossRef
    31.Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ. Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009;33(3):279鈥?6.PubMed CrossRef
    32.Oleson DR, Magee RM, Donahoe RM, Falek A, Coles CD. Immunity and prenatal alcohol exposure. A pilot study in human adolescents. Adv Exp Med Biol. 1998;437:255鈥?4.PubMed CrossRef
    33.Johnson S, Knight R, Marmer DJ, Steele RW. Immune deficiency in fetal alcohol syndrome. Pediatr Res. 1981;15(6):908鈥?1.PubMed CrossRef
    34.Castells S, Mark E, Abaci F, Schwartz E. Growth retardation in fetal alcohol syndrome. Unresponsiveness to growth-promoting hormones. Dev Pharmacol Ther. 1981;3(4):232鈥?1.PubMed
    35.Burd L, Peterson L, Kobrinsky N. Fetal alcohol spectrum disorders and childhood cancer: a concise review of case reports and future research considerations. Pediatr Blood Cancer. 2014;61(5):768鈥?0.PubMed CrossRef
    36.Barker DJ. Sir Richard Doll lecture. Developmental origins of chronic disease. Public Health. 2012;126(3):185鈥?.PubMed CrossRef
    37.McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, et al. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol. 2009;182(12):7803鈥?.PubMed Central PubMed CrossRef
    38.Zhang X, Lan N, Bach P, Nordstokke D, Yu W, Ellis L, et al. Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. Brain Behav Immun. 2012;26(3):439鈥?0.PubMed Central PubMed CrossRef
    39.Chen L, Nyomba BL. Effects of prenatal alcohol exposure on glucose tolerance in the rat offspring. Metab Clin Exp. 2003;52(4):454鈥?2.PubMed CrossRef
    40.Pennington JS, Shuvaeva TI, Pennington SN. Maternal dietary ethanol consumption is associated with hypertriglyceridemia in adult rat offspring. Alcohol Clin Exp Res. 2002;26(6):848鈥?5.PubMed CrossRef
    41.Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014;384(9943):626鈥?5. doi:10.鈥?016/鈥媠0140-6736(14)61177-6 .PubMed CrossRef
    42.Polanco TA, Crismale-Gann C, Reuhl KR, Sarkar DK, Cohick WS. Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats. Alcohol Clin Exp Res. 2010;34(11):1879鈥?7.PubMed CrossRef
    43.Murugan S, Zhang C, Mojtahedzadeh S, Sarkar DK. Alcohol exposure in utero increases susceptibility to prostate tumorigenesis in rat offspring. Alcohol Clin Exp Res. 2013;37(11):1901鈥?.PubMed CrossRef
    44.Catts VS, Fung SJ, Long LE, Joshi D, Vercammen A, Allen KM, et al. Rethinking schizophrenia in the context of normal neurodevelopment. Front Cell Neurosci. 2013;7:60.PubMed Central PubMed CrossRef
    45.Lebel C, Gee M, Camicioli R, Wieler M, Martin W, Beaulieu C. Diffusion tensor imaging of white matter tract evolution over the lifespan. NeuroImage. 2012;60(1):340鈥?2.PubMed CrossRef
    46.Lebel C, Mattson SN, Riley EP, Jones KL, Adnams CM, May PA, et al. A longitudinal study of the long-term consequences of drinking during pregnancy: heavy in utero alcohol exposure disrupts the normal processes of brain development. J Neurosci. 2012;32(44):15243鈥?1.PubMed Central PubMed CrossRef
    47.Treit S, Lebel C, Baugh L, Rasmussen C, Andrew G, Beaulieu C. Longitudinal MRI reveals altered trajectory of brain development during childhood and adolescence in fetal alcohol spectrum disorders. J Neurosci. 2013;33(24):10098鈥?09.PubMed CrossRef
    48.Gautam P, Nunez SC, Narr KL, Kan EC, Sowell ER. Effects of prenatal alcohol exposure on the development of white matter volume and change in executive function. NeuroImage Clin. 2014;5:19鈥?7.PubMed Central PubMed CrossRef
    49.Giedd JN, Raznahan A, Alexander-Bloch A, Schmitt E, Gogtay N, Rapoport JL. Child psychiatry branch of the National Institute of Mental Health longitudinal structural magnetic resonance imaging study of human brain development. Neuropsychopharmacol. 2015;40(1):43鈥?.CrossRef
    50.Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104(49):19649鈥?4.PubMed Central PubMed CrossRef
    51.Barbaresi WJ, Colligan RC, Weaver AL, Voigt RG, Killian JM, Katusic SK. Mortality, ADHD, and psychosocial adversity in adults with childhood ADHD: a prospective study. Pediatrics. 2013;131(4):637鈥?4.PubMed Central PubMed CrossRef
    52.Hart H, Rubia K. Neuroimaging of child abuse: a critical review. Front Hum Neurosci. 2012;6:52.PubMed Central PubMed CrossRef
    53.Dykens EM. Aging in rare intellectual disability syndromes. Dev Disabil Res Rev. 2013;18(1):75鈥?3.PubMed CrossRef
    54.Zigman WB. Atypical aging in Down syndrome. Dev Disabil Res Rev. 2013;18(1):51鈥?7.PubMed CrossRef
    55.Ness KK, Krull KR, Jones KE, Mulrooney DA, Armstrong GT, Green DM, et al. Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31(36):4496鈥?03.CrossRef
    56.Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL. Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry. 2010;67(6):531鈥?.PubMed Central PubMed CrossRef
    57.Moretti L, Cristofori I, Weaver SM, Chau A, Portelli JN, Grafman J. Cognitive decline in older adults with a history of traumatic brain injury. Lancet Neurol. 2012;11(12):1103鈥?2.PubMed CrossRef
    58.Tucker AM, Stern Y. Cognitive reserve in aging. Curr Alzheimer Res. 2011;8(4):354鈥?0.PubMed Central PubMed CrossRef
    59.Stern Y. Cognitive reserve in ageing and Alzheimer鈥檚 disease. The Lancet Neurol. 2012;11(11):1006鈥?2.PubMed CrossRef
  • 作者单位:Eileen M. Moore (1)
    Edward P. Riley (1)

    1. Center for Behavioral Teratology, San Diego State University, 6330 Alvarado Court, Suite 100, San Diego, CA, 92120, USA
  • 刊物类别:Psychiatry; Pediatrics; General Practice / Family Medicine;
  • 刊物主题:Psychiatry; Pediatrics; General Practice / Family Medicine;
  • 出版者:Springer International Publishing
  • ISSN:2196-2987
文摘
The range of structural abnormalities and functional deficits caused by prenatal alcohol exposure (PAE) are referred to as fetal alcohol spectrum disorders (FASDs). The disabilities associated with FASDs are said to be lifelong, but we know relatively little regarding outcomes beyond childhood and adolescence. Many of physical, brain, and neurobehavioral features that are present in children with FASDs will endure to adulthood. However, some features may diminish or change over time. Furthermore, secondary disabilities, such as school dropouts, trouble with the law, and substance/alcohol abuse problems are common in young adults with FASDs. The health consequences associated with PAE in the human adult are unknown, but animal models suggest that they may be more susceptible to chronic diseases such as hypertension, diabetes, immune dysfunction, and cancer. More research is needed to understand the lasting effects of PAE on adults and the developmental trajectories of FASDs. Keywords Fetal alcohol spectrum disorders Adult Health Cognition Behavior

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