Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder

详细信息    查看全文

• 作者：Annegret Krause-Utz ; Rachel Frost ; Dorina Winter…
• 关键词：Dissociation ; Trauma ; Borderline personality disorder ; Posttraumatic stress disorder (PTSD) ; Depersonalization disorder ; Dissociative identity disorder ; Neuroimaging ; Brain structure and function
• 刊名：Current Psychiatry Reports
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：797KB
• 刊物主题：Psychiatry;
• 出版者：Springer US
• ISSN：1535-1645
• 卷排序：19

文摘

Dissociation involves disruptions of usually integrated functions of consciousness, perception, memory, identity, and affect (e.g., depersonalization, derealization, numbing, amnesia, and analgesia). While the precise neurobiological underpinnings of dissociation remain elusive, neuroimaging studies in disorders, characterized by high dissociation (e.g., depersonalization/derealization disorder (DDD), dissociative identity disorder (DID), dissociative subtype of posttraumatic stress disorder (D-PTSD)), have provided valuable insight into brain alterations possibly underlying dissociation. Neuroimaging studies in borderline personality disorder (BPD), investigating links between altered brain function/structure and dissociation, are still relatively rare. In this article, we provide an overview of neurobiological models of dissociation, primarily based on research in DDD, DID, and D-PTSD. Based on this background, we review recent neuroimaging studies on associations between dissociation and altered brain function and structure in BPD. These studies are discussed in the context of earlier findings regarding methodological differences and limitations and concerning possible implications for future research and the clinical setting.