Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development

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• 作者：Martin M. Johansson ; Elin Lundin ; Xiaoyan Qian…
• 关键词：Sex differences ; Human embryo development ; Female ; Male ; Gene expression ; Protocadherin ; Neuroligin ; X chromosome ; Y chromosome ; Brain ; Spinal cord ; Cortex ; Medulla oblongata ; Rolling circle amplification ; PCDH11X ; PCDH11Y ; NLGN4X ; NLGN4Y ; ISLET1 ; OLIG2 ; SOX10 ; NeuN
• 刊名：Biology of Sex Differences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：1
• 全文大小：3,917 KB
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• 作者单位：Martin M. Johansson (1)
  Elin Lundin (2)
  Xiaoyan Qian (2)
  Mohammadreza Mirzazadeh (1)
  Jonatan Halvardson (3)
  Elisabeth Darj (4) (5)
  Lars Feuk (3)
  Mats Nilsson (2)
  Elena Jazin (1)
  
  1. Department of Organismal Biology, EBC, Uppsala University, Uppsala, Sweden
  2. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
  3. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  4. Department of Women’s and Children’s Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden
  5. Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
  
• 刊物主题：Human Physiology; Endocrinology;
• 出版者：BioMed Central
• ISSN：2042-6410

文摘

Background Renewed attention has been directed to the functions of the Y chromosome in the central nervous system during early human male development, due to the recent proposed involvement in neurodevelopmental diseases. PCDH11Y and NLGN4Y are of special interest because they belong to gene families involved in cell fate determination and formation of dendrites and axon.