A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice
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- 作者：Emma L. Burrows ; Liliana Laskaris ; Lynn Koyama ; Leonid Churilov…
- 关键词：Autism ; Brain disorder ; Cognitive disorder ; Gene mutation ; Mutant mice ; Neuroligin ; 3 ; Psychiatric disorder ; Repetitive and restrictive behavior ; Social interaction ; Synaptic protein
- 刊名：Molecular Autism
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：1
- 全文大小：1,010 KB
- 刊物主题：Neurology; Neurosciences; Neuropsychology; Molecular Medicine; Psychiatry; Pediatrics;
- 出版者：BioMed Central
- ISSN：2040-2392
文摘
Background Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in social communication and repetitive behavior. Risperidone, an atypical antipsychotic, is widely used to treat aggression in ASD. In order to understand the neurobiological underpinnings of these challenging behaviors, a thorough characterisation of behavioral endophenotypes in animal models is required.