Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited

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• 作者：Kongkiat Kulkantrakorn (1) (2)
  
• 关键词：Pyridoxine ; Toxicity ; Ataxia ; Neuronopathy ; Neuropathy
• 刊名：Neurological Sciences
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：35
• 期：11
• 页码：1827-1830
• 全文大小：138 KB
• 参考文献：1. Chung JY, Choi JH, Hwang CY, Youn HY (2008) Pyridoxine induced neuropathy by subcutaneous administration in dogs. J Vet Sci 9:127-31 CrossRef
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• 作者单位：Kongkiat Kulkantrakorn (1) (2)
  
  1. Neurology Division, Department of Internal Medicine, Thammasat University, Rangsit Campus, Pathumthani, 12120, Thailand
  2. Neuroscience Center, Bangkok Hospital Medical Center Bangkok Hospital Group, Bangkok, 10310, Thailand
  
• ISSN：1590-3478

文摘

High dose pyridoxine is neurotoxic. Previous case reports were sparse and little is known about the clinical and electrodiagnostic findings. Three patients with pyridoxine-induced sensory ataxic neuropathy were studied and a review of the involved literature was performed. Three patients, aged 80, 83 and 83?years old, presented with sensory ataxia for 3-?months. Examination showed signs of polyneuropathy and sensory ataxia. Six hundred milligrams of pyridoxine was consumed each day for 3-0?years, in the form of vitamin B1-6-12 combination tablet. Investigations for other causes of neuropathy were unremarkable. Blood levels of vitamin B6 were markedly elevated at 104.6, 81.4 and 66.9 times of upper normal limits. Electrodiagnostic tests showed symmetric axonal sensory polyneuropathy in two patients. Two years after vitamin discontinuation, all patients showed no significant improvement in the neuropathy and gait. In conclusion, consumption of high dose pyridoxine can cause sensory neuronopathy and axonal sensorimotor polyneuropathy, leading to sensory ataxia which may not be reversible.