Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

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• 作者：Mitsuhiro Yoshimura ; Yasuhito Uezono ; Yoichi Ueta
• 关键词：Hypothalamus ; Feeding ; regulating neuropeptides ; Anorexia ; Behavior ; Rodents
• 刊名：The Journal of Physiological Sciences
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：65
• 期：5
• 页码：385-395
• 全文大小：1,125 KB
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• 作者单位：Mitsuhiro Yoshimura (1)
  Yasuhito Uezono (2)
  Yoichi Ueta (1)
  
  1. Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan
  2. Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan
  
• 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
• 出版者：Springer Japan
• ISSN：1880-6562

文摘

Anorexia, a loss of appetite for food, can be caused by various physiological and pathophysiological conditions. In this review, firstly, clinical aspects of anorexia nervosa are summarized in brief. Secondly, hypothalamic neuropeptides responsible for feeding regulation in each hypothalamic nucleus are discussed. Finally, three different types of anorexigenic animal models; dehydration-induced anorexia, cisplatin-induced anorexia and cancer anorexia-cachexia, are introduced. In conclusion, hypothalamic neuropeptides may give us novel insight to understand and find effective therapeutics strategy essential for various kinds of anorexia. Keywords Hypothalamus Feeding-regulating neuropeptides Anorexia Behavior Rodents