Verbal episodic memory in 426 multiple sclerosis patients: impairment in encoding, retrieval or both?

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• 作者：H. Brissart (123)
  E. Morele (3) elodie.morele@hotmail.fr
  C. Baumann (24)
  M. Debouverie (1234)
• 关键词：Multiple sclerosis &#8211 ; Verbal episodic memory &#8211 ; Neuropsychology
• 刊名：Neurological Sciences
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：33
• 期：5
• 页码：1117-1123
• 全文大小：189.4 KB
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• 作者单位：1. Department of Neurology, Central Hospital, Avenue du Mar茅chal de Lattre de Tassigny, CHU de Nancy, 54035 Nancy Cedex, France2. Nancy-Universit茅, Universit茅 Paul Verlaine Metz, Universit茅 Paris Descartes, EA 4360 Apemac, Nancy, France3. LORSEP Group, 1 rue du Vivarais, 54500 Vandoeuvre Les Nancy, France4. INSERM, CIC-EC CIE6, Nancy, France
• ISSN：1590-3478

文摘

Episodic memory is frequently impaired in multiple sclerosis (MS) patients but the exact nature of the disorder is controversial. It was initially thought to be due to a retrieval deficit but some studies have demonstrated an encoding deficit, which could be linked to a slowing of information processing speed or to a deficit in elaboration of strategies. The main objective of this study is to assess the prevalence and the nature of verbal episodic memory (VEM) impairment in MS patients. We retrieved memory performances of 426 patients [314 F–112 M; mean age: 46.1 years; median Expanded Disability Status Scale (EDSS) score: 3.1] from a neuropsychological data base. VEM was assessed using the 16 words RL-RI 16 test. 66% MS patients present at least one recall impaired in VEM (37.2% from 2 to 5 recall). 14.2% MS patients present an impairment in encoding phase. We observed that 5% of patients presented recognition difficulties. Correlations were observed between VEM performances and EDSS, and disease duration but no group effect (ANOVA) is observed between form of MS and VEM performances. These results confirm the high prevalence of VEM impairment in MS patients. Deficits affect mainly information retrieval in early stage MS patients and are then linked to encoding as disability increases. Storage disorders are infrequent, so cognitive rehabilitation with mental imaging could be effective in MS patients.