Definition and characterization of an extended social-affective default network

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• 作者：Maren Amft (1)
  Danilo Bzdok (1) (6)
  Angela R. Laird (3) (4)
  Peter T. Fox (4) (5)
  Leonhard Schilbach (2)
  Simon B. Eickhoff (1) (6)
  
  1. Institute of Clinical Neuroscience and Medical Psychology ; HHU D眉sseldorf ; D眉sseldorf ; Germany
  6. Institut f眉r Neurowissenschaften und Medizin (INM-1) ; Forschungszentrum J眉lich GmbH ; 52425 ; J眉lich ; Germany
  3. Department of Physics ; Florida International University ; Miami ; USA
  4. Research Imaging Institute ; University of Texas Health Science Center at San Antonio ; San Antonio ; USA
  5. South Texas Veterans Administration Medical Center ; San Antonio ; Texas
  2. Department of Psychiatry ; University of Cologne ; Cologne ; Germany
  
• 关键词：Default mode network ; Meta ; analytic connectivity modeling ; Resting ; state functional connectivity ; Social cognition ; Emotion
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：220
• 期：2
• 页码：1031-1049
• 全文大小：4,593 KB
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• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.