Induction of hypoxia-inducible factor-1α by BDNF protects retinoblastoma cells against chemotherapy-induced apoptosis

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• 作者：Yu Gao ; Ming Jing ; Rongrong Ge ; Lili Lang
• 关键词：Retinoblastoma ; Brain ; derived neurotrophic factor ; Hypoxia ; inducible factor ; 1α ; Chemotherapy resistance
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：414
• 期：1-2
• 页码：77-84
• 全文大小：1,565 KB
• 参考文献：1.McCarthy N (2012) Retinoblastoma: epigenetic outcome. Nat Rev Cancer 12:80CrossRef
  2.Villegas VM, Hess DJ, Wildner A, Gold AS, Murray TG (2013) Retinoblastoma. Curr Opin Ophthalmol 24:581–588CrossRef PubMed
  3.Friedman DN, Sklar CA, Oeffinger KC, Kernan NA, Khakoo Y, Marr BP, Wolden SL, Abramson DH, Dunkel IJ (2013) Long-term medical outcomes in survivors of extra-ocular retinoblastoma: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience. Pediatr Blood Cancer 60:694–699CrossRef PubMed
  4.Stannard C, Sauerwein W, Maree G, Lecuona K (2013) Radiotherapy for ocular tumours. Eye (Lond) 27:119–127CrossRef
  5.Shields CL, Bianciotto CG, Jabbour P, Griffin GC, Ramasubramanian A, Rosenwasser R, Shields JA (2011) Intra-arterial chemotherapy for retinoblastoma: report no. 2, treatment complications. Arch Ophthalmol 129:1407–1415CrossRef PubMed
  6.Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820–823CrossRef PubMed PubMedCentral
  7.Stephan H, Zakrzewski JL, Bölöni R, Grasemann C, Lohmann DR, Eggert A (2008) Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. Pediatr Blood Cancer 50:218–222CrossRef PubMed
  8.Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD (1990) NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5:501–509CrossRef PubMed
  9.Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H (2010) BDNF function and intracellular signaling in neurons. Histol Histopathol 25:237–258PubMed
  10.Washiyama K, Muragaki Y, Rorke LB, Lee V, Feinstein SC, Radeke MJ, Blumberg D, Kaplan D, Trojanowski J (1996) Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. Am J Pathol 148:929–940PubMed PubMedCentral
  11.Chiappa SA, Chin LS, Zurawel RH, Raffel C (1999) Neurotrophins and Trk receptors in primitive neuroectodermal tumor cell lines. Neurosurgery 45:1148–1154CrossRef PubMed
  12.Jaboin J, Kim CJ, Kaplan DR, Thiele CJ (2002) Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Cancer Res 62:6756–6763PubMed
  13.Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51–56CrossRef PubMed PubMedCentral
  14.Semenza GL (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 33:207–214CrossRef PubMed PubMedCentral
  15.Lee J-W, Bae S-H, Jeong J-W, Kim S-H, Kim K-W (2004) Hypoxia-inducible factor (HIF-1) α: its protein stability and biological functions. Exp Mol Med 36:1–12CrossRef PubMed
  16.Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721–732CrossRef PubMed
  17.Nakamura K, Martin KC, Jackson JK, Beppu K, Woo C-W, Thiele CJ (2006) Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1α in neuroblastoma cells. Cancer Res 66:4249–4255CrossRef PubMed
  18.Hammond JB, Kruger NJ (1988) The bradford method for protein quantitation. Methods Mol Biol 3:25–32PubMed
  19.Zhu X, Wang K, Zhang K, Zhu L, Zhou F (2014) Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicol Lett 227:65–73CrossRef PubMed
  20.Friedman WJ, Greene LA (1999) Neurotrophin signaling via Trks and p75. Exp Cell Res 253:131–142CrossRef PubMed
  21.Roux PP, Barker PA (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67:203–233CrossRef PubMed
  22.Johnson JE, Barde Y-A, Schwab M, Thoenen H (1986) Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J Neurosci 6:3031–3038PubMed
  23.Colafrancesco V, Parisi V, Sposato V, Rossi S, Russo MA, Coassin M, Lambiase A, Aloe L (2011) Ocular application of nerve growth factor protects degenerating retinal ganglion cells in a rat model of glaucoma. J Glaucoma 20:100–108CrossRef PubMed
  24.Frade JM, Bovolenta P, Rodriguez-Tebar A (1999) Neurotrophins and other growth factors in the generation of retinal neurons. Microsc Res Tech 45:243–251CrossRef PubMed
  25.Rohwer N, Cramer T (2011) Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat 14:191–201CrossRef PubMed
  26.Majmundar AJ, Wong WJ, Simon MC (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40:294–309CrossRef PubMed PubMedCentral
  27.Patel J, Landers K, Mortimer RH, Richard K (2010) Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development. Placenta 31:951–957CrossRef PubMed
  28.Halterman MW, Federoff HJ (1999) HIF-1α and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol 159:65–72CrossRef PubMed
  29.Greijer A, Van der Wall E (2004) The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57:1009–1014CrossRef PubMed PubMedCentral
  30.Zhang Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV, Le AD (2004) Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int J Cancer 111:849–857CrossRef PubMed
  
• 作者单位：Yu Gao (1)
  Ming Jing (1)
  Rongrong Ge (1)
  Lili Lang (2)
  
  1. Department of Ophthalmology, No. 411 Hospital of CPLA, Shanghai, 200081, China
  2. Department of Ophthalmology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200081, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Medical Biochemistry
  Oncology
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4919

文摘

Alternations of environment signals such as neurotrophins may be the basis for malignant transformation of retinoblastoma (Rb), the most common primary intraocular malignancy in children. The aim of this study is to investigate the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of Rb cells to the common chemotherapeutic agents and to explore the role of hypoxia-inducible factor-1α (HIF-1α) in such cellular process. The results showed that BDNF could induce higher expression of HIF-1α via activation of TrkB in human Y-79 retinoblastoma cells, which consequently contributed to its effect against chemotherapeutic agent-induced cytotoxicity and cell apoptosis. However, this protective effect could be potently reversed by knockdown of HIF-1α. Furthermore, BDNF strikingly prevented chemotherapeutic agent-induced alternations of apoptosis-related molecules, which could also be attenuated by silencing HIF-1α. Therefore, our findings demonstrated that BDNF could contribute to chemoresistance of Rb via modulation of HIF-1α expression, indicating that targeting at the BDNF-TrkB/HIF-1α signaling pathway might be a promising strategy for the treatment of retinoblastoma in the future.