Prospective cohort study of procalcitonin levels in children with cancer presenting with febrile neutropenia
详细信息 查看全文
- 作者：Victoria Hemming ; Adam D. Jakes ; Geoff Shenton ; Bob Phillips
- 关键词：Febrile Neutropenia ; Procalcitonin ; Clinical decision rules ; Paediatric ; Cancer ; Risk stratification
- 刊名：BMC Pediatrics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：804KB
- 刊物主题：Pediatrics; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2431
- 卷排序：17
文摘
BackgroundFebrile neutropenia (FNP) causes significant morbidity and mortality in children undergoing treatment for cancer. The development of clinical decision rules to help stratify risks in paediatric FNP patients and the use of inflammatory biomarkers to identify high risk patients is an area of recent research. This study aimed to assess if procalcitonin (PCT) levels could be used to help diagnose or exclude severe infection in children with cancer who present with febrile neutropenia, both as a single measurement and in addition to previously developed clinical decision rules.