Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis

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• 作者：Julia A. Hayanga ; Senelisiwe P. Ngubane ; Alfred N. Murunga…
• 关键词：Grapefruit juice ; Diabetes ; Insulin ; Gluconeogenesis
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：55
• 期：2
• 页码：631-638
• 全文大小：504 KB
• 参考文献：1.Florida department of citrus: history of dieting, Florida, Department of Citrus, Lakeland FL, 2003
  2.Bailey DG, Spence JD, Edgar B, Bayliff CD, Arnold JM (1989) Ethanol enhances the hemodynamic effects of felodipine. Clin Invest Med 12:357–362
  3.Lundahl J, Regårdh CG, Edgar B, Johnsson G (1997) Effects of grapefruit juice ingestion-pharmacokinetics and haemodynamics of intravenously administered felodipine in healthy men. Eur J Clin Pharmacol 52:139–145CrossRef
  4.Saito Hirata-Koizumi M, Matsumoto M et al (2005) Undesirable effects of citrus juice on pharmacokinetics of drugs: focus on recent studies. Drug Saf 28:677–694CrossRef
  5.Christensen H, Asberg A, Holmboe AB, Berg KJ (2002) Co-administration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. Eur J Clin Pharmacol 58:515–520CrossRef
  6.Zaidenstein Dishi V, Gips M et al (1998) The effect of grapefruit juice on pharmacokinetics of orally administered verapamil. Eur J Clin Pharm 54:337–340CrossRef
  7.Kupferschmidt HH, Fattinger KE, Ha HR et al (1998) Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol 45:355–359CrossRef
  8.Gorinstein S, Leontowiwicz TH, Leontowicz M et al (2005) Red Star Ruby (Sunrise) and blood quantities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets. Life Sci 77:2384–2397CrossRef
  9.Gorinstein S, Caspi A, Libman I et al (2006) Red grapefruit positively influences serum triglycerides level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agric Food Chem 54:1887–1892CrossRef
  10.Fujioka Greenway F, Sheard J et al (2006) The effects of grapefruit juice on weight and insulin resistance: relationship to metabolic syndrome. J Med Food 9:49–54CrossRef
  11.Owira PMO, Ojewole JAO (2009) Grapefruit juice improves glycemic control but also exacerbates metformin-induced lactic acidosis in non-diabetic rats. Methods Find Exp Clin Pharmacol 31:563–570
  12.Seifter S, Dayton S et al (1950) The estimation of glycogen with anthrone reagent. Arch Biochem Biophys 25:191–200
  13.Davidson AL, Arion WJ (1987) Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity. Arch Biochem Biophys 253:156–167CrossRef
  14.Barzila N, Roseseti L (1993) Role of glucokinase and glucose-6-phosphate in the acute and chronic regulation of hepatic glucose fluxes by insulin. J Biol Chem 268:25019–25025
  15.Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 72:248–254CrossRef
  16.Lange AJ, Arion WJ, Burchell A et al (1986) Aluminum ions are required for stabilization and inhibition of hepatic microsomal glucose-6-phosphatase by sodium fluoride. J Biol Chem 261:101–107
  17.Bentle LA, Lardy HA (1976) Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase. J Biol Chem 251:2916–2921
  18.Stiffin RM, Sullivan SM, Carlson GM et al (2008) Differential inhibition of cytosolic PEPCK by substrate analogues. Kinetic and structural characterization of inhibitor recognition. Biochemistry 47:2099–2109CrossRef
  19.Sundaram B, Singhal K, Sandhir R (2011) Ameliorating effect of chromium administration on hepatic glucose metabolism in streptozotocin-induced experimental diabetes. BioFactors 38:59–68CrossRef
  20.Postic C, Shiota M, Niswender KD, Jetton TL et al (1999) Dual roles for glucokinase in glucose homeostasis as determined by rat liver and β cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274:305–315CrossRef
  21.Herling AW, Burger HJ, Schwab D et al (1998) Pharmacodynamic profile of a novel inhibitor of the hepatic glucose-6-phosphatase system. Am J Physiol 274:G1087–G1093
  22.Kim YD, Park KG, Lee YS et al (2008) Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase—dependent regulation of the orphan nuclear receptor SHP. Diabetes 57:306–314CrossRef
  23.Jung UJ, Lee MK, Park YB et al (2006) Effects of citrus flavonoids on lipid metabolism and glucose-regulating enzymes mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38:1134–1145CrossRef
  24.Purushotham A, Tian M, Belury MA (2008) The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells. Mol Nutr Food Res 53(2):300–307CrossRef
  25.Jung UJ, Lee MK, Jeong KS et al (2004) Hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 134:2499–2503
  26.Xulu S, Owira PMO (2012) Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. J Cardiovasc Pharmacol 59:133–141CrossRef
  
• 作者单位：Julia A. Hayanga (1)
  Senelisiwe P. Ngubane (1)
  Alfred N. Murunga (1)
  Peter M. O. Owira (1)
  
  1. Discipline of Pharmaceutical Sciences, Department of Pharmacology, School of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose Hypoglycemic effects of grapefruit juice (GFJ) are widely recognized, but the mechanism(s) by which GFJ lowers blood glucose levels have not previously been investigated.