Induction of apoptosis in anoikis-resistant breast cancer stem cells by supercritical CO2 extracts from Citrus hassaku Hort ex Tanaka
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- 作者：Linh Thi Thao Nguyen (2)
Yeon Woo Song (2)
Thao Anh Tran (2)
Ki-Seok Kim (3)
Somi Kim Cho (1) (2) - 关键词：anoikis ; breast cancer stem cell ; citrus fruits ; Citrus hassaku ; supercritical CO2 extracts
- 刊名：Journal of the Korean Society for Applied Biological Chemistry
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：57
- 期：4
- 页码：469-472
- 全文大小：252 KB
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Yeon Woo Song (2)
Thao Anh Tran (2)
Ki-Seok Kim (3)
Somi Kim Cho (1) (2)
2. Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju, 690-756, Republic of Korea
3. Department of Medicine, School of Medicine, Jeju National University, Jeju, 690-756, Republic of Korea
1. Subtropical Horticulture Research Institute, Jeju National University, Jeju, 690-756, Republic of Korea - ISSN：2234-344X
文摘
Anoikis (or cell-detachment-induced apoptosis) is a special form of apoptosis in which cells loose contact with other cells or the extracellular matrix. In the present study, we have found that the breast cancer stem cell line MCF-7-SC, isolated from MCF-7 breast cancer cells, shows characteristics of anoikis resistance. Treatment of supercritical CO2 extract from Citrus hassaku Hort ex Tanaka, locally known as Phalsak, reduced the expression of ATP-binding cassette sub-family G member 2 mRNA and induced apoptosis in MCF-7-SCs, as evidenced by an increase of apoptotic body formation, increased cell population in the sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolytic activation of caspase-9 and caspase-3, and the degradation of poly(ADP-ribose) polymerase (PARP) protein. The effects of supercritical CO2 extract from Phalsak on anoikis-resistant breast cancer stem cells suggest the use of this extract as a potential therapeutic agent for breast cancer stem cell treatment.