Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort
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- 作者：Eric J. Duell (1) (2)
Leila Lujan-Barroso (1) (2)
Claudia Llivina (1) (2)
Xavier Muoz (1) (2)
Mazda Jenab (3)
Marie-Christine Boutron-Ruault (4) (5) (6)
Franoise Clavel-Chapelon (4) (5) (6)
Antoine Racine (4) (5) (6)
Heiner Boeing (7)
Brian Buijsse (7)
Federico Canzian (8)
Theron Johnson (8)
Christine Dalgrd (9)
Kim Overvad (10)
Anne Tjnneland (11)
Anja Olsen (11)
Soledad C. Schez (12)
Emilio Schez-Cantalejo (13) (14)
JosMar Huerta (14) (15)
Eva Ardanaz (14) (15) (16)
Miren Dorronsoro (14) (15) (16) (17)
Kay-Tee Khaw (18)
Ruth C. Travis (19)
Antonia Trichopoulou (20)
Dimitrios Trichopoulos (20) (21)
Snorri Rafnsson (20)
Domenico Palli (22)
Carlotta Sacerdote (23) (24)
Rosario Tumino (25)
Salvatore Panico (26)
Sara Grioni (27)
H. Bas Bueno-de-Mesquita (28) (29)
Martine M. Ros (28)
Mattijs E. Numans (30) (31)
Petra H. Peeters (32)
Dorthe Johansen (33)
Bjrn Lindkvist (34)
Mattias Johansson (35) (36)
Ingegerd Johansson (37)
Guri Skeie (38)
Elisabete Weiderpass (38) (39) (40)
Talita Duarte-Salles (3)
Roger Stenling (41)
Elio Riboli (42)
Nia Sala (1) (2)
Carlos A. Gonzez (1) (2) - 关键词：Gastric cancer ; Vitamin C ; Antioxidants ; Genetic susceptibility ; SLC23A1 ; SLC23A2
- 刊名：Genes & Nutrition
- 出版年：2013
- 出版时间：November 2013
- 年：2013
- 卷：8
- 期：6
- 页码：549-560
- 全文大小：
- 作者单位：Eric J. Duell (1) (2)
Leila Lujan-Barroso (1) (2)
Claudia Llivina (1) (2)
Xavier Muoz (1) (2)
Mazda Jenab (3)
Marie-Christine Boutron-Ruault (4) (5) (6)
Franoise Clavel-Chapelon (4) (5) (6)
Antoine Racine (4) (5) (6)
Heiner Boeing (7)
Brian Buijsse (7)
Federico Canzian (8)
Theron Johnson (8)
Christine Dalgrd (9)
Kim Overvad (10)
Anne Tjnneland (11)
Anja Olsen (11)
Soledad C. Schez (12)
Emilio Schez-Cantalejo (13) (14)
JosMar Huerta (14) (15)
Eva Ardanaz (14) (15) (16)
Miren Dorronsoro (14) (15) (16) (17)
Kay-Tee Khaw (18)
Ruth C. Travis (19)
Antonia Trichopoulou (20)
Dimitrios Trichopoulos (20) (21)
Snorri Rafnsson (20)
Domenico Palli (22)
Carlotta Sacerdote (23) (24)
Rosario Tumino (25)
Salvatore Panico (26)
Sara Grioni (27)
H. Bas Bueno-de-Mesquita (28) (29)
Martine M. Ros (28)
Mattijs E. Numans (30) (31)
Petra H. Peeters (32)
Dorthe Johansen (33)
Bjrn Lindkvist (34)
Mattias Johansson (35) (36)
Ingegerd Johansson (37)
Guri Skeie (38)
Elisabete Weiderpass (38) (39) (40)
Talita Duarte-Salles (3)
Roger Stenling (41)
Elio Riboli (42)
Nia Sala (1) (2)
Carlos A. Gonzez (1) (2)
1. Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, alan Institute of Oncology (ICO), Avda Gran Via 199-203, 08908 Lospitalet de Llobregat, Barcelona, Spain
2. Bellvitge Biomedical Research Institute (IDIBELL), Lospitalet de Llobregat, Barcelona, Spain
3. Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France
4. Inserm, Centre for Research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women Health Team, Villejuif, France
5. Paris Sud University, Villejuif, France
6. Institute Gustave Roussy, Villejuif, France
7. Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrke, Germany
8. German Cancer Research Center (DKFZ), Heidelberg, Germany
9. Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark
10. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
11. Danish Cancer Society Research Center, Copenhagen, Denmark
12. Public Health Directorate, Asturias, Spain
13. Andalusian School of Public Health, Granada, Spain
14. CIBER Epidemiolog y Salud Plica (CIBERESP), Madrid, Spain
15. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain
16. Navarre Public Health Institute, Pamplona, Spain
17. Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebasti, Spain
18. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
19. Cancer Epidemiology Unit, University of Oxford, Oxford, UK
20. Hellenic Health Foundation, Athens, Greece
21. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
22. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy
23. Center for Cancer Prevention (CPO-Piemonte), Turin, Italy
24. Human Genetic Foundation (HuGeF), Turin, Italy
25. Cancer Registry and Histopathology Unit, ivile M.P. ArezzoHospital, ASP, Ragusa, Italy
26. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
27. Epidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
28. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
29. Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
30. Department of Primary Care Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
31. Department of General Practice and Elderly Care, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
32. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
33. Department of Surgery, Skne University Hospital, Malm, Sweden
34. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
35. Genetic Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France
36. Department of Biobank Research, Faculty of Medicine, Ume University, Ume, Sweden
37. Department of Odontology, Ume University, Ume, Sweden
38. Department of Community Medicine, University of Troms, Troms, Norway
39. Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
40. Samfundet Folkhlsan, Helsinki, Finland
41. Department of Medical Biosciences, Pathology, Ume University, Ume, Sweden
42. School of Public Health, Imperial College London, London, UK - ISSN：1865-3499
文摘
Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR=1.63, 95% CI=1.11.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.