Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
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- 作者：Nicholas J White (26) (27)
Elizabeth A Ashley (26)
Judith Recht (26)
Michael J Delves (28)
Andrea Ruecker (28)
Frank M Smithuis (27) (29)
Alice C Eziefula (30)
Teun Bousema (30)
Chris Drakeley (30)
Kesinee Chotivanich (26) (32)
Mallika Imwong (26) (31)
Sasithon Pukrittayakamee (26) (32)
Jetsumon Prachumsri (33)
Cindy Chu (26) (34)
Chiara Andolina (26) (34)
Germana Bancone (26) (34)
Tran T Hien (35)
Mayfong Mayxay (36)
Walter RJ Taylor (26)
Lorenz von Seidlein (26)
Ric N Price (26) (37)
Karen I Barnes (38)
Abdoulaye Djimd茅 (39)
Feiko ter Kuile (40)
Roly Gosling (41)
Ingrid Chen (41)
Mehul J Dhorda (27) (42)
Kasia Stepniewska (42)
Philippe Gu茅rin (42)
Charles J Woodrow (26) (27)
Arjen M Dondorp (26) (27)
Nicholas PJ Day (26) (27)
Francois H Nosten (26) (27) (34)
26. Mahidol Oxford Tropical Medicine Research Unit ; Faculty of Tropical Medicine ; Mahidol University ; Bangkok ; Thailand
27. Centre for Tropical Medicine and Global Health ; Nuffield Department of Medicine ; University of Oxford ; Oxford ; UK
28. Department of Life Sciences ; Imperial College ; London ; UK
29. Myanmar Oxford Clinical Research Unit ; Yangon ; Myanmar
30. London School of Hygiene and Tropical Medicine ; London ; UK
32. Department of Clinical Tropical Medicine ; Faculty of Tropical Medicine ; Mahidol University ; Bangkok ; Thailand
31. Department of Molecular Tropical Medicine and Genetics ; Faculty of Tropical Medicine ; Mahidol University ; Bangkok ; Thailand
33. Mahidol Vivax Research Unit ; Faculty of Tropical Medicine ; Mahidol University ; Bangkok ; Thailand
34. Shoklo Malaria Research Unit ; Faculty of Tropical Medicine ; Mahidol University ; Mae Sot ; Tak ; Thailand
35. Oxford University Clinical Research Unit ; Hospital for Tropical Diseases ; Ho Chi Minh City ; Vietnam
36. Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit ; Microbiology Laboratory ; Mahosot Hospital ; Vientiane ; Lao PDR
37. Global and Tropical Health Division ; Menzies School of Health Research and Charles Darwin University ; Darwin ; NT ; Australia
38. Division of Clinical Pharmacology ; Department of Medicine ; University of Cape Town ; Cape Town ; South Africa
39. Malaria Research and Training Centre ; Department of Epidemiology of Parasitic Diseases ; Faculty of Medicine and Odonto-Stomatogy ; University of Sciences ; Techniques and Technologies of Bamako ; Bamako ; Mali
40. Liverpool School of Tropical Medicine ; Liverpool ; UK
41. Global Health Group ; UCSF Global Health Sciences ; San Francisco ; CA ; USA
42. World Wide Antimalarial Resistance Network ; Churchill Hospital ; Oxford ; Headington ; UK - 刊名：Malaria Journal
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：13
- 期：1
- 全文大小：2,292 KB
- 参考文献：Guidelines for the Treatment of Malaria. World Health Organization, Geneva
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- 出版者：BioMed Central
- ISSN：1475-2875
文摘
Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.