Insights into Spray Development from Metered-Dose Inhalers Through Quantitative X-ray Radiography

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• 作者：Nicholas Mason-Smith ; Daniel J. Duke ; Alan L. Kastengren…
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：33
• 期：5
• 页码：1249-1258
• 全文大小：676 KB
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• 作者单位：Nicholas Mason-Smith (1)
  Daniel J. Duke (2)
  Alan L. Kastengren (3)
  Peter J. Stewart (4)
  Daniela Traini (5)
  Paul M. Young (5)
  Yang Chen (5)
  David A. Lewis (6)
  Julio Soria (1) (7)
  Daniel Edgington-Mitchell (1)
  Damon Honnery (1)
  
  1. Laboratory for Turbulence Research in Aerospace and Combustion, Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, Australia
  2. Energy Systems Division, Argonne National Laboratory, Lemont, Illinois, USA
  3. X-ray Science Division, Argonne National Laboratory, Lemont, Illinois, USA
  4. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia
  5. Respiratory Technology, Woolcock Institute of Medical Research and the Discipline of Pharmacology, Sydney Medical School, Sydney, Australia
  6. Chiesi Ltd, Chippenham, UK
  7. Department of Aeronautical Engineering, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X

文摘

Purpose Typical methods to study pMDI sprays employ particle sizing or visible light diagnostics, which suffer in regions of high spray density. X-ray techniques can be applied to pharmaceutical sprays to obtain information unattainable by conventional particle sizing and light-based techniques.