Limited cross-border infections in patients newly diagnosed with HIV in Europe
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- 作者：Dineke Frentz (1)
Annemarie M J Wensing (2)
Jan Albert (3) (4)
Dimitrios Paraskevis (5)
Ana B Abecasis (6)
Osamah Hamouda (7)
Louise B J?rgensen (8)
Claudia Kücherer (7)
Daniel Struck (9)
Jean-Claude Schmit (10) (9)
Birgitta ?sj? (11)
Claudia Balotta (12)
Danail Beshkov (13)
Ricardo J Camacho (14) (6)
Bonaventura Clotet (15)
Suzie Coughlan (16)
Stéphane De Wit (17)
Algirdas Griskevicius (18)
Zehava Grossman (19)
Andrzej Horban (20)
Tatjana Kolupajeva (21)
Klaus Korn (22)
Leondios G Kostrikis (23)
Kirsi Liitsola (24)
Marek Linka (25)
Claus Nielsen (8)
Dan Otelea (26)
Roger Paredes (16)
Mario Poljak (27)
Elisabeth Puchhammer-St?ckl (28)
Anders S?nnerborg (29) (4)
Danica Stanekova (30)
Maja Stanojevic (31)
Anne-Mieke Vandamme (32) (6)
Charles A B Boucher (1)
David A M C Van de Vijver (1) - 关键词：Europe ; HIV ; 1 ; Transmission ; Clusters
- 刊名：Retrovirology
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：10
- 期：1
- 全文大小：205KB
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Annemarie M J Wensing (2)
Jan Albert (3) (4)
Dimitrios Paraskevis (5)
Ana B Abecasis (6)
Osamah Hamouda (7)
Louise B J?rgensen (8)
Claudia Kücherer (7)
Daniel Struck (9)
Jean-Claude Schmit (10) (9)
Birgitta ?sj? (11)
Claudia Balotta (12)
Danail Beshkov (13)
Ricardo J Camacho (14) (6)
Bonaventura Clotet (15)
Suzie Coughlan (16)
Stéphane De Wit (17)
Algirdas Griskevicius (18)
Zehava Grossman (19)
Andrzej Horban (20)
Tatjana Kolupajeva (21)
Klaus Korn (22)
Leondios G Kostrikis (23)
Kirsi Liitsola (24)
Marek Linka (25)
Claus Nielsen (8)
Dan Otelea (26)
Roger Paredes (16)
Mario Poljak (27)
Elisabeth Puchhammer-St?ckl (28)
Anders S?nnerborg (29) (4)
Danica Stanekova (30)
Maja Stanojevic (31)
Anne-Mieke Vandamme (32) (6)
Charles A B Boucher (1)
David A M C Van de Vijver (1)
1. Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
2. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands
3. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
4. Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
5. National Retrovirus Reference Center, Department of Hygiene Epidemiology of Medical Statistics, Medical School, University of Athens, Athens, Greece
6. Centro de Malária e outras Doen?as Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
7. Robert Koch-Institute, Berlin, Germany
8. Statens Serum Institute, Copenhagen, Denmark
9. Laboratory of Retrovirology, CRP-Santé, Luxembourg, Luxembourg
10. Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
11. Section for Microbiology and Immunology,The Gade Institute, University of Bergen, Bergen, Norway
12. University of Milan, Milan, Italy
13. Department of Virology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
14. Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
15. irsiCaixa AIDS Research Institute & Lluita contra la SIDA Foundation, Hospital Universitari ”Germans Trias i Pujol- Badalona, Spain
16. University College Dublin, Dublin, Ireland
17. Department of Infectious Diseases, St Pierre University Hospital, Brussels, Belgium
18. National Public Health Surveillance Laboratory, Vilnius, Lithuania
19. School of Public Health, Tel-Aviv University, Tel Aviv, Israel
20. Warsaw Medical University and Hospital of Infectious Diseases, Warsaw, Poland
21. Infectology Center of Latvia, Riga, Latvia
22. University of Erlangen-Nuremberg, Erlangen, Germany
23. University of Cyprus, Nicosia, Cyprus
24. National Institute for Health and Welfare, Helsinki, Finland
25. National Institute of Public Health, Prague, Czech Republic
26. Molecular Diagnostics, ”Prof. Dr. Matei Bals-Institute for Infectious Diseases, Bucharest, Romania
27. University of Ljubljana, Ljubljana, Slovenia
28. Medical University Vienna, Vienna, Austria
29. Divisions of Infectious Diseases and Clinical Virology, Karolinska Institute, Stockholm, Sweden
30. Slovak Medical University, Bratislava, Slovakia
31. School of Medicine, University of Belgrade, Belgrade, Serbia
32. Rega Institute for Medical Research, KU Leuven, Leuven, Belgium - ISSN：1742-4690
文摘
Background International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045). Conclusions Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.