Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning -an ultrahigh-field MR pilot study
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- 作者：Tim Sinnecker (1) (2)
Timm Oberwahrenbrock (1)
Imke Metz (3)
Hanna Zimmermann (1)
Caspar F. Pfueller (1) (4)
Lutz Harms (4) (5)
Klemens Ruprecht (4) (5)
Caren Ramien (1)
Katrin Hahn (5)
Wolfgang Brück (3)
Thoralf Niendorf (6) (7)
Friedemann Paul (1) (4) (5) (7)
Alexander U. Brandt (1)
Jan D?rr (1) (4)
Jens Wuerfel (1) (6) (8) - 关键词：Multiple sclerosis ; Magnetic resonance imaging ; Retinal nerve fibre layer ; Optic radiation ; Trans ; synaptic degeneration
- 刊名：European Radiology
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：25
- 期：1
- 页码：122-131
- 全文大小：2,607 KB
- 参考文献：1. Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292-02 ternal" href="http://dx.doi.org/10.1002/ana.22366" target="_blank" title="It opens in new window">CrossRef
2. Filippi M, Bozzali M, Rovaris M et al (2003) Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 126:433-37 ternal" href="http://dx.doi.org/10.1093/brain/awg038" target="_blank" title="It opens in new window">CrossRef
3. Oberwahrenbrock T, Ringelstein M, Jentschke S et al (2013) Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome. Mult Scler 19:1887-895 ternal" href="http://dx.doi.org/10.1177/1352458513489757" target="_blank" title="It opens in new window">CrossRef
4. Kitajima M, Korogi Y, Takahashi M, Eto K (1996) MR signal intensity of the optic radiation. AJNR Am J Neuroradiol 17:1379-383
5. Bürgel U, Mecklenburg I, Blohm U, Zilles K (1997) Histological visualization of long fiber tracts in the white matter of adult human brains. J Hirnforsch 38:397-04
6. Sinnecker T, Mittelstaedt P, D?rr J et al (2012) Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Arch Neurol 69:739-45
7. Kollia K, Maderwald S, Putzki N et al (2009) First clinical study on ultra-high-field MR imaging in patients with multiple sclerosis: comparison of 1.5T and 7T. AJNR Am J Neuroradiol 30:699-02 ternal" href="http://dx.doi.org/10.3174/ajnr.A1434" target="_blank" title="It opens in new window">CrossRef
8. Kilsdonk ID, Wattjes MP, Lopez-Soriano A et al (2014) Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla. Eur Radiol 24:841-49 ternal" href="http://dx.doi.org/10.1007/s00330-013-3080-y" target="_blank" title="It opens in new window">CrossRef
9. Kilsdonk ID, de Graaf WL, Barkhof F, Wattjes MP (2012) Inflammation high-field magnetic resonance imaging. Neuroimaging Clin N Am 22:135-57 ternal" href="http://dx.doi.org/10.1016/j.nic.2012.02.010" target="_blank" title="It opens in new window">CrossRef
10. Tallantyre EC, Dixon JE, Donaldson I et al (2011) Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions. Neurology 76:534-39 ternal" href="http://dx.doi.org/10.1212/WNL.0b013e31820b7630" target="_blank" title="It opens in new window">CrossRef
11. Wuerfel J, Sinnecker T, Ringelstein EB et al (2012) Lesion morphology at 7 Tesla MRI differentiates Susac syndrome from multiple sclerosis. Mult Scler 18:1592-599 ternal" href="http://dx.doi.org/10.1177/1352458512441270" target="_blank" title="It opens in new window">CrossRef
12. D?rr J, Krautwald S, Wildemann B et al (2013) Characteristics of Susac syndrome: a review of all reported cases. Nat Rev Neurol 9:307-16 ternal" href="http://dx.doi.org/10.1038/nrneurol.2013.82" target="_blank" title="It opens in new window">CrossRef
13. Sinnecker T, D?rr J, Pfueller CF et al (2012) Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Neurology 79:708-14 ternal" href="http://dx.doi.org/10.1212/WNL.0b013e3182648bc8" target="_blank" title="It opens in new window">CrossRef
14. Petzold A, de Boer JF, Schippling S et al (2010) Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 9:921-32 ternal" href="http://dx.doi.org/10.1016/S1474-4422(10)70168-X" target="_blank" title="It opens in new window">CrossRef
15. Oberwahrenbrock T, Schippling S, Ringelstein M et al (2012) Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography. Mult Scler Int 2012:530305
16. Trip SA, Schlottmann PG, Jones SJ et al (2005) Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 58:383-91 ternal" href="http://dx.doi.org/10.1002/ana.20575" target="_blank" title="It opens in new window">CrossRef
17. Pueyo V, Martin J, Fernandez J et al (2008) Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis. Mult Scler 14:609-14 ternal" href="http://dx.doi.org/10.1177/1352458507087326" target="_blank" title="It opens in new window">CrossRef
18. Wu GF, Schwartz ED, Lei T et al (2007) Relation of vision to global and regional brain MRI in multiple sclerosis. Neurology 69:2128-135 ternal" href="http://dx.doi.org/10.1212/01.wnl.0000278387.15090.5a" target="_blank" title="It opens in new window">CrossRef
19. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). - 作者单位：Tim Sinnecker (1) (2)
Timm Oberwahrenbrock (1)
Imke Metz (3)
Hanna Zimmermann (1)
Caspar F. Pfueller (1) (4)
Lutz Harms (4) (5)
Klemens Ruprecht (4) (5)
Caren Ramien (1)
Katrin Hahn (5)
Wolfgang Brück (3)
Thoralf Niendorf (6) (7)
Friedemann Paul (1) (4) (5) (7)
Alexander U. Brandt (1)
Jan D?rr (1) (4)
Jens Wuerfel (1) (6) (8)
1. NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany
2. Department of Neurology, Asklepios Fachklinikum Teupitz, Teupitz, Germany
3. Institute of Neuropathology, University Medicine Goettingen, Goettingen, Germany
4. Clinical and Experimental Multiple Sclerosis Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany
5. Department of Neurology, Charité - Universitaetsmedizin Berlin, Berlin, Germany
6. Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center for Molecular Medicine, Berlin, Germany
7. Experimental and Clinical Research Center, Charité -Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
8. Institute of Neuroradiology, University Medicine Goettingen, Goettingen, Germany - ISSN：1432-1084
文摘
Objective To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7?T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT). Methods We studied 7?T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n--6) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness. Results Optic radiation lesion volume was associated with thinning of the optic radiation (p--.001), delayed VEP (p--.031), and visual disability indicated by FACT (p--.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p--.001), including patients without previous optic neuritis (p--.001). Conclusions Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7?T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances. Key Points -Focal destruction of the optic radiation is detectable by 7?T MRI. -Focal optic radiation damage is common in MS. -Optic radiation damage is associated with RNFL thinning, detectable by OCT. -Optic radiation damage is associated with delayed VEP and visual dysfunction. -RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.