Plaque vulnerability of coronary artery lesions is related to left ventricular dilatation as determined by optical coherence tomography and cardiac magnetic resonance imaging in patients with type 2 diabetes

详细信息    查看全文

• 作者：Mathias Burgmaier (1)
  Michael Frick (1)
  Ana Liberman (1)
  Simone Battermann (1)
  Martin Hellmich (2)
  Walter Lehmacher (2)
  Agnes Jaskolka (3)
  Nikolaus Marx (1)
  Sebastian Reith (1)
  
• 关键词：Type 2 diabetes mellitus ; Cardiac magnetic resonance imaging ; Optical coherence tomography ; Minimal fibrous cap thickness ; Coronary plaque morphology
• 刊名：Cardiovascular Diabetology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：12
• 期：1
• 全文大小：373KB
• 参考文献：1. Burke AP, Kolodgie FD, Zieske A, Fowler DR, Weber DK, Varghese PJ, Farb A, Virmani R: Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. / Arterioscler Thromb Vasc Biol 2004,24(7):1266-271. CrossRef
  2. Chia S, Raffel OC, Takano M, Tearney GJ, Bouma BE, Jang IK: Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study. / Diabetes Res Clin Pract 2008,81(2):155-60. CrossRef
  3. Emmett L, Van Gaal WJ, Magee M, Bass S, Ali O, Freedman SB, Van der Wall H, Kritharides L: Prospective evaluation of the impact of diabetes and left ventricular hypertrophy on the relationship between ischemia and transient ischemic dilation of the left ventricle on single-day adenosine Tc-99m myocardial perfusion imaging. / J Nucl Cardiol 2008,15(5):638-43. CrossRef
  4. Feng T, Yundai C, Lian C, Zhijun S, Changfu L, Jun G, Hongbin L: Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina pectoris. / Atherosclerosis 2010,213(2):482-85. CrossRef
  5. Hong YJ, Jeong MH, Choi YH, Ko JS, Lee MG, Kang WY, Lee SE, Kim SH, Park KH, Sim DS, / et al.: Plaque characteristics in culprit lesions and inflammatory status in diabetic acute coronary syndrome patients. / JACC Cardiovasc Imaging 2009,2(3):339-49. CrossRef
  6. Marso SP, House JA, Klauss V, Lerman A, Margolis P, Leon MB: Diabetes mellitus is associated with plaque classified as thin cap fibroatheroma: an intravascular ultrasound study. / Diab Vasc Dis Res 2010,7(1):14-9. CrossRef
  7. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. / N Engl J Med 1998,339(4):229-34. CrossRef
  8. Kannel WB, Hjortland M, Castelli WP: Role of diabetes in congestive heart failure: the Framingham study. / Am J Cardiol 1974,34(1):29-4. CrossRef
  9. Kubo T, Nakamura N, Matsuo Y, Okumoto Y, Wu X, Choi SY, Komukai K, Tanimoto T, Ino Y, Kitabata H, / et al.: Virtual histology intravascular ultrasound compared with optical coherence tomography for identification of thin-cap fibroatheroma. / Int Heart J 2011,52(3):175-79. CrossRef
  10. Lowe HC, Narula J, Fujimoto JG, Jang IK: Intracoronary optical diagnostics current status, limitations, and potential. / JACC Cardiovasc Interv 2011,4(12):1257-270. CrossRef
  11. Reith S, Battermann S, Jaskolka A, Lehmacher W, Hoffmann R, Marx N, Burgmaier M: Relationship between optical coherence tomography derived intraluminal and intramural criteria and haemodynamic relevance as determined by fractional flow reserve in intermediate coronary stenoses of patients with type 2 diabetes. / Heart 2013,99(10):700-07. CrossRef
  12. Reith S, Battermann S, Jaskolka A, Lehmacher W, Hoffmann R, Marx N, Burgmaier M: Predictors and incidence of stent edge dissections in patients with type 2 diabetes as determined by optical coherence tomography. / Int J Cardiovasc Imaging 2013. in press
  13. Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, Bouma B, Bruining N, Cho JM, Chowdhary S, / et al.: Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. / J Am Coll Cardiol 2012,59(12):1058-072. CrossRef
  14. Barlis P, Gonzalo N, Di Mario C, Prati F, Buellesfeld L, Rieber J, Dalby MC, Ferrante G, Cera M, Grube E, / et al.: A multicentre evaluation of the safety of intracoronary optical coherence tomography. / Euro Intervention 2009,5(1):90-5.
  15. Hausmann D, Erbel R, Alibelli-Chemarin MJ, Boksch W, Caracciolo E, Cohn JM, Culp SC, Daniel WG, De Scheerder I, DiMario C, / et al.: The safety of intracoronary ultrasound. A multicenter survey of 2207 examinations. / Circulation 1995,91(3):623-30. CrossRef
  16. Hudsmith LE, Petersen SE, Francis JM, Robson MD, Neubauer S: Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. / J Cardiovasc Magn Reson 2005,7(5):775-82. CrossRef
  17. Alfakih K, Plein S, Thiele H, Jones T, Ridgway JP, Sivananthan MU: Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences. / J Magn Reson Imaging 2003,17(3):323-29. CrossRef
  18. Pujadas S, Reddy GP, Weber O, Lee JJ, Higgins CB: MR imaging assessment of cardiac function. / J Magn Reson Imaging 2004,19(6):789-99. CrossRef
  19. Lorenz CH, Walker ES, Morgan VL, Klein SS, Graham TP Jr: Normal human right and left ventricular mass, systolic function, and gender differences by cine magnetic resonance imaging. / J Cardiovasc Magn Reson 1999,1(1):7-1. CrossRef
  20. Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F, Iftima N, Shishkov M, Houser S, Aretz HT, Halpern EF, / et al.: In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. / Circulation 2005,111(12):1551-555. CrossRef
  21. Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, Kauffman CR, Shishkov M, Kang DH, Halpern EF, / et al.: Characterization of human atherosclerosis by optical coherence tomography. / Circulation 2002,106(13):1640-645. CrossRef
  22. Yonetsu T, Kakuta T, Lee T, Takahashi K, Kawaguchi N, Yamamoto G, Koura K, Hishikari K, Iesaka Y, Fujiwara H, / et al.: In vivo critical fibrous cap thickness for rupture-prone coronary plaques assessed by optical coherence tomography. / Eur Heart J 2011,32(10):1251-259. CrossRef
  23. Swets JA: Measuring the accuracy of diagnostic systems. / Science 1988,240(4857):1285-293. CrossRef
  24. Young ME, Guthrie PH, Razeghi P, Leighton B, Abbasi S, Patil S, Youker KA, Taegtmeyer H: Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. / Diabetes 2002,51(8):2587-595. CrossRef
  25. Burgmaier M, Sen S, Philip F, Wilson CR, Miller CC 3rd, Young ME, Taegtmeyer H: Metabolic adaptation follows contractile dysfunction in the heart of obese Zucker rats fed a high-fat “Western-diet. / Obesity (Silver Spring) 2010,18(10):1895-901. CrossRef
  26. Ntaios G, Gatselis NK, Makaritsis K, Dalekos GN: Adipokines as mediators of endothelial function and atherosclerosis. / Atherosclerosis 2013,227(2):216-21. CrossRef
  27. van Diepen JA, Berbee JF, Havekes LM, Rensen PC: Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. / Atherosclerosis 2013,228(2):306-15. CrossRef
  28. Romero-Bermejo FJ, Ruiz-Bailen M, Gil-Cebrian J, Huertos-Ranchal MJ: Sepsis-induced cardiomyopathy. / Curr Cardiol Rev 2011,7(3):163-83. CrossRef
  29. Chahal NS, Lim TK, Jain P, Chambers JC, Kooner JS, Senior R: The distinct relationships of carotid plaque disease and carotid intima-media thickness with left ventricular function. / J Am Soc Echocardiogr 2010,23(12):1303-309. CrossRef
  30. Madaj PM, Pagali SR, Hamirani YS, Raina S, Nair S, Zeb I, Mao S, Budoff MJ: Coronary artery calcium and plaque association with left ventricular mass, assessed by multi-row detector computed tomography. / Coron Artery Dis 2010,21(7):428-34. CrossRef
  31. Heckbert SR, Post W, Pearson GD, Arnett DK, Gomes AS, Jerosch-Herold M, Hundley WG, Lima JA, Bluemke DA: Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. / J Am Coll Cardiol 2006,48(11):2285-292. CrossRef
  32. Hamon M, Fau G, Nee G, Ehtisham J, Morello R: Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease. / J Cardiovasc Magn Reson 2010,12(1):29. CrossRef
  33. Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, / et al.: A prospective natural-history study of coronary atherosclerosis. / N Engl J Med 2011,364(3):226-35. CrossRef
  
• 作者单位：Mathias Burgmaier (1)
  Michael Frick (1)
  Ana Liberman (1)
  Simone Battermann (1)
  Martin Hellmich (2)
  Walter Lehmacher (2)
  Agnes Jaskolka (3)
  Nikolaus Marx (1)
  Sebastian Reith (1)
  
  1. Department of Internal Medicine I, University Hospital of the RWTH Aachen, Aachen, Germany
  2. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany
  3. Interdisciplinary Center of Clinical Research (IZKF), University Hospital of the RWTH Aachen, Aachen, Germany
  

文摘

Background Patients with type 2 diabetes are at increased risk for both, left ventricular (LV)-dilatation and myocardial infarction (MI) following the rupture of a vulnerable plaque. This study investigated the to date incompletely understood relationship between plaque vulnerability and LV-dilatation using optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) in patients with type 2 diabetes and stable coronary artery disease. Methods CMR was performed in 58 patients with type 2 diabetes, in which 81 coronary lesions were investigated using OCT. Results A decreased minimal fibrous cap thickness (FCT) of coronary lesions was associated with an increase of several CMR-derived parameters including LV-end diastolic volume (LVEDV, r--.521, p-lt;-.001), LV-end diastolic diameter (r--.502, p-lt;-.001) and LV-end systolic volume (r--.467, p--.001). Similar results were obtained for mean FCT. Furthermore, patients with dilated versus non-dilated LV differed significantly in several cardiovascular risk factors including previous MI (47.1% vs. 14.6%, p--.009), HDL-cholesterol (40.35?±-.57?mg/dl vs. 45.20?±-0.79?mg/dl, p--.029) and smoking (82.4% vs. 51.2%, p--.027). However, minimal FCT is associated to LV-dilatation independent of previous MIs (odds ratio 0.679, p--.022). Receiver-operating curve analysis demonstrated that CMR-derived LVEDV predicts plaque vulnerability with low-moderate diagnostic efficiency (area under the curve 0.699) and considerate specificity (83.3%) at the optimal cut-off value (159.0?ml). Conclusion These data suggest that vulnerability of coronary lesions is associated with LV-dilatation in high risk patients with type 2 diabetes. CMR may be a useful adjunct to the risk-stratification in this population. Future studies are warranted to investigate potential mechanisms linking plaque vulnerability and LV-dilatation.