Neuronal human BACE1 knockin induces systemic diabetes in mice

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• 作者：Kaja Plucińska ; Ruta Dekeryte ; David Koss ; Kirsty Shearer ; Nimesh Mody…
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：59
• 期：7
• 页码：1513-1523
• 全文大小：1,450 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428
• 卷排序：59

文摘

Aimsβ-Secretase 1 (BACE1) is a key enzyme in Alzheimer’s disease pathogenesis that catalyses the amyloidogenic cleavage of amyloid precursor protein (APP). Recently, global Bace1 deletion was shown to protect against diet-induced obesity and diabetes, suggesting that BACE1 is a potential regulator of glucose homeostasis. Here, we investigated whether increased neuronal BACE1 is sufficient to alter systemic glucose metabolism, using a neuron-specific human BACE1 knockin mouse model (PLB4).