miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA

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• 作者：Yu-Fang Xia ; Gui-Hua Pei ; Ning Wang ; Yan-Ci Che ; Feng-Sheng Yu…
• 关键词：MicroRNAs ; Cervical cancer ; Human papillomavirus ; SLC6A6
• 刊名：Virology Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：7642KB
• 刊物主题：Virology;
• 出版者：BioMed Central
• ISSN：1743-422X
• 卷排序：14

文摘

BackgroundCervical cancer (CC) is the second most common cancer in females in developing countries. The two viral oncoproteins E6 and E7 mediate the oncogenic activities of high-risk human papillomavirus (HR-HPV), and HR-HPV, especially HPV16 or/and HPV18 (HPV16/18) play critical roles in CC through different pathways. microRNAs (miRNAs) may be associated with CC pathogenesis. Researches have indicated that human papillomavirus (HPV) may regulate cellular miRNA expression through viral E6 and E7. Herein, the purposes of this study were to identify the relationship between HPV infection and aberrantly expressed miRNAs and to investigate their pathogenic roles in CC.