Efficient derivation of dopaminergic neurons from SOX1↿/sup> floor plate cells under defined culture conditions
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- 作者：Mingming Li ; Yu Zou ; Qiqi Lu ; Ning Tang ; Alexis Heng…
- 关键词：Human embryonic stem cells ; Neural conversion ; Floor plate ; LDN193189 ; SB431541 ; PD173074 ; Dopaminergic neurons
- 刊名：Journal of Biomedical Science
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：23
- 期：1
- 全文大小：3,123 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine - 出版者：Springer Netherlands
- ISSN：1423-0127
文摘
Background Parkinson’s disease (PD) is a severe neurodegenerative disease associated with loss of dopaminergic neurons. Derivation of dopaminergic neurons from human embryonic stem cells (hESCs) could provide new therapeutic options for PD therapy. Dopaminergic neurons are derived from SOX− floor plate (FP) cells during embryonic development in many species and in human cell culture in vitro. Early treatment with sonic hedgehog (Shh) has been reported to efficiently convert hESCs into FP lineages.