New scoring methodology improves the sensitivity of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in clinical trials

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• 作者：Nishant Verma ; S. Natasha Beretvas ; Belen Pascual…
• 刊名：Alzheimer's Research & Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：7
• 期：1
• 全文大小：2,291 KB
• 刊物主题：Neurosciences; Neurology; Geriatrics/Gerontology;
• 出版者：BioMed Central
• ISSN：1758-9193

文摘

Introduction As currently used, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) has low sensitivity for measuring Alzheimer’s disease progression in clinical trials. A major reason behind the low sensitivity is its sub-optimal scoring methodology, which can be improved to obtain better sensitivity.