Metachronous double cancer after curative resection for pancreatic adenocarcinoma: report of four cases

详细信息    查看全文

• 作者：Yoshito Ikematsu (1)
  Hiroaki Tamura (1)
  Tadataka Hayashi (1)
  Yuji Tokunaga (2)
  Yuki Misawa (3)
  Hiroki Mori (4)
  Shinichi Hasegawa (5)
  Taketoshi Okawada (5)
  Takachika Ozawa (4)
  Shigeru Momiki (6)
  Yoshiro Nishiwaki (1)
  
• 关键词：Pancreas cancer ; Metachronous cancer ; Gemcitabine
• 刊名：Clinical Journal of Gastroenterology
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：5
• 期：2
• 页码：108-112
• 全文大小：339KB
• 参考文献：1. Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605-7. CrossRef
  2. Japan Pancreas Society. Trend of overall survival of the patients with histologically confirmed invasive pancreatic cancer. Suizo 2007;22:e37–e38.
  3. International Union Against Cancer. TNM classification of malignant tumours. New York: Wiley-Liss; 2002.
  4. Ikematsu Y, Tamura H, Nakata Y, Hayashi T, Kanai T, Hirayama K, et al. Metachronous multiple adenocarcinomas of the pancreas. Int J Clin Oncol. 2011;6:726-1.
  5. Park IJ, Yu CS, Kim HC, Jung YH, Han KR, Kim JC. Metachronous colorectal cancer. Colorectal Dis. 2006;8:323-. CrossRef
  6. Eriguchi N, Aoyagi S, Hara M, Okuda K, Tamae T, Fukuda S, et al. Synchronous or metachronous double cancers of the pancreas and other organs: report on 12 cases. Surg Today. 2000;30:718-1. CrossRef
  7. Ikeuchi N, Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, et al. Prognosis of cancer with branch duct type IPMN of the pancreas. World J Gastroenterol. 2010;16:1890-. CrossRef
  8. Sawai Y, Yamao K, Bhatia V, Chiba T, Mizuno N, Sawaki A, et al. Development of pancreatic cancers during long-term follow-up of side-branch intraductal papillary mucinous neoplasms. Endoscopy. 2010;42:1077-4. CrossRef
  9. Takaori K. Current understanding of precursors to pancreatic cancer. J Hepatobiliary Pancreat Surg. 2007;14:217-3. CrossRef
  10. Tanno S, Nakano Y, Koizumi K, Sugiyama Y, Nakamura K, Sasajima J, et al. Pancreatic ductal adenocarcinomas in long-term follow-up patients with branch duct intraductal papillary mucinous neoplasms. Pancreas. 2010;39:36-0. CrossRef
  11. Calculli L, Pezzilli R, Brindisi C, Morabito R, Casadei R, Zompatori M. Pancreatic and extrapancreatic lesions in patients with intraductal papillary mucinous neoplasms of the pancreas: a single-centre experience. Radiol Med. 2010;115:442-2. CrossRef
  12. Eguchi H, Ishikawa O, Ohigashi H, Tomimaru Y, Sasaki Y, Yamada T, et al. Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development. Surgery. 2006;139:749-4. CrossRef
  13. Ishida M, Egawa S, Kawaguchi K, Aoki T, Sakata N, Mikami Y, et al. Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. Pancreatology. 2008;8:577-2. CrossRef
  14. Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007;297:267-7. CrossRef
  15. Ueno H, Kosuge T, Matsuyama Y, Yamamoto J, Nakao A, Egawa S, et al. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer. 2009;101:908-5. CrossRef
  
• 作者单位：Yoshito Ikematsu (1)
  Hiroaki Tamura (1)
  Tadataka Hayashi (1)
  Yuji Tokunaga (2)
  Yuki Misawa (3)
  Hiroki Mori (4)
  Shinichi Hasegawa (5)
  Taketoshi Okawada (5)
  Takachika Ozawa (4)
  Shigeru Momiki (6)
  Yoshiro Nishiwaki (1)
  
  1. Department of Surgery, Hamamatsu Medical Center, 328 Tomitsuka, Hamamatsu, Shizuoka, 432-8580, Japan
  2. Department of Breast Surgery, Hamamatsu Medical Center, Hamamatsu, Japan
  3. Department of Otorhinolaryngology, Hamamatsu Medical Center, Hamamatsu, Japan
  4. Department of Pathology, Hamamatsu Medical Center, Hamamatsu, Japan
  5. Department of Radiology, Hamamatsu Medical Center, Hamamatsu, Japan
  6. Department of Thoracic Surgery, Hamamatsu Medical Center, Hamamatsu, Japan
  

文摘

We experienced four cases of metachronous double cancer after curative resection for pancreatic adenocarcinoma without the background of intraductal papillary mucinous neoplasm. Case 1, a 67-year-old Japanese female developed tongue cancer 53?months after a pylorus-preserving Whipple resection for pancreatic head adenocarcinoma. Case 2, a 66-year-old female developed multiple breast cancers 52?months after a pylorus-preserving pancreaticoduodenectomy for pancreatic head adenocarcinoma. Case 3, a 59-year-old male developed an adenocarcinoma in the remnant pancreatic head 63?months after a distal pancreatectomy for pancreatic body cancer. Case 4, a 68-year-old male developed lung cancer 92?months after a Whipple procedure for pancreatic head adenocarcinoma. Gemcitabine was administered to three patients as adjuvant chemotherapy at an average administrated dose of 38,199?mg per body surface area. Since primary pancreatic ductal adenocarcinoma is aggressive and always associated with a devastating outcome, metachronous double cancer is scarcely seen. All four cases received curative-intent surgery for each metachronous cancer and were alive for at least 20?months.