Endothelial nitric oxide synthase gene polymorphisms are associated with sensitization to seasonal aeroallergens in asthmatic children

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• 作者：Maria Iordanidou ; Emmanouil Paraskakis ; Anna Tavridou…
• 关键词：Key wordsasthma ; atopy ; genetics ; nitric oxide
• 刊名：World Journal of Pediatrics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：13
• 期：1
• 页码：34-40
• 全文大小：
• 刊物主题：Pediatrics; Pediatric Surgery; Maternal and Child Health; Intensive / Critical Care Medicine; Surgery; Imaging / Radiology;
• 出版者：Childrens Hospital, Zhejiang University School of Medicine
• ISSN：1867-0687
• 卷排序：13

文摘

BackgroundChildhood asthma phenotype is the consequence of interaction between environment and genetic factors. Nitric oxide (NO) formation is affected by polymorphisms in nitric oxide synthase (NOS) enzymes, which play a significant role as inflammatory factors in the airways. This study was undertaken to estimate the correlation of -786C>T and 894G>T polymorphisms of the eNOS gene with the sensitization of asthmatic children to common aeroallergens.