1-Stearoylglycerol is associated with risk of prostate cancer: results from a serum metabolomic profiling analysis

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• 作者：Alison M. Mondul ; Steven C. Moore ; Stephanie J. Weinstein ; Satu M?nnist?…
• 关键词：Metabolomics ; Prostatic neoplasms ; Prospective study ; Nested case–control study ; Early detection ; Biomarker
• 刊名：Metabolomics
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：10
• 期：5
• 页码：1036-1041
• 全文大小：171 KB
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• 作者单位：Alison M. Mondul (1)
  Steven C. Moore (1)
  Stephanie J. Weinstein (1)
  Satu M?nnist? (2)
  Joshua N. Sampson (3)
  Demetrius Albanes (1)
  
  1. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 9609 Medical Center Drive, 6E328, Bethesda, MD, 20892, USA
  2. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
  3. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA
  
• ISSN：1573-3890

文摘

Although prostate cancer is the most commonly diagnosed cancer among men in developed populations, recent recommendations against routine prostate-specific antigen screening have cast doubt on its utility for early detection. We compared the metabolomic profiles of prospectively collected fasting serum from 74 prostate cancer cases and 74 controls selected from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers. Circulating 1-stearoylglycerol (1-SG, or 1-monostearin) was statistically significantly inversely associated with risk of prostate cancer after Bonferroni correction for multiple comparisons (i.e., 420 identified metabolites) (OR 0.34, 95?% CI 0.20-.58, p 6.3?×?10?). The magnitude of this association did not differ by disease aggressiveness and was observed for cases diagnosed up to 23?years after blood collection. Similar but somewhat weaker prostate cancer risk signals were also evident for glycerol and alpha-ketoglutarate. In this population, men with higher serum 1-SG were less likely to develop prostate cancer, supporting a role for dysregulation of lipid metabolism in this malignancy. Additional studies are needed to retest the association and to examine 1-SG for its potential as a prostate cancer early detection marker.