Tobacco nitrosamines as culprits in disease: mechanisms reviewed

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• 作者：Emine Yalcin ; Suzanne de la Monte
• 关键词：Tobacco ; specific nitrosamine ; NNK ; Smoking ; Nicotine ; Carcinogenesis ; Adduct ; Neurodegeneration ; Diabetes ; Tobacco
• 刊名：Journal of Physiology and Biochemistry
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：72
• 期：1
• 页码：107-120
• 全文大小：948 KB
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• 作者单位：Emine Yalcin (1)
  Suzanne de la Monte (1)
  
  1. Departments of Pathology (Neuropathology), Neurology, and Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, 55 Claverick Street, Room 419, Providence, RI, 02903, USA
  
• 刊物主题：Biomedicine general; Human Physiology; Animal Physiology;
• 出版者：Springer Netherlands
• ISSN：1877-8755

文摘

The link between tobacco abuse and cancer is well-established. However, emerging data indicate that toxins in tobacco smoke cause cellular injury due to enhanced toxic/metabolic effects of metabolites, disruption of intracellular signaling mechanisms, and formation of DNA, protein, and lipid adducts that impair function and promote oxidative stress and inflammation. These effects of smoking, which are largely non-carcinogenic, can be produced by tobacco-specific nitrosamines and their metabolites. These factors could account for the increased rates of neurodegeneration and insulin resistance diseases among smokers. Herein, we review nicotine and tobacco-specific nitrosamine metabolism, mechanisms of adduct formation, DNA damage, mutagenesis, and potential mechanisms of disease.