A non-surgical method for induction of lung cancer in Wistar rats using a combination of NNK and high dietary fats
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- 作者：Shilpa Bhatnagar (1)
Naveen Chaudhary (1)
Deepshikha Pande Katare (2)
S. K. Jain (1) - 关键词：NNK ; Histopathology ; Lung tumours ; Oxidative damage
- 刊名：Protoplasma
- 出版年：2013
- 出版时间：August 2013
- 年：2013
- 卷：250
- 期：4
- 页码：919-929
- 全文大小：659KB
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Naveen Chaudhary (1)
Deepshikha Pande Katare (2)
S. K. Jain (1)
1. Department of Biotechnology, Hamdard University, Hamdard Nagar, New Delhi, 110062, India
2. Amity Institute of Biotechnology, Amity University, Noida, 201303, Uttar Pradesh, India
文摘
Lung cancer is one of the most common malignant neoplasms all over the world. Smoking and a number of constituents of tobacco are responsible for development of lung tumours; however, the deleterious effects of tobacco-derived carcinogen, nitrosamine 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (nicotine-derived nitrosamine ketone (NNK)) remain unmatched. We report the development of a novel rodent model by administering multiple doses of NNK to male Wistar rats and feeding them with high-fat and low-protein diet. Tumour cells in lungs were observed in approximately 98?% rats after 8?months of NNK treatment, as evident by histopathological analysis. This rodent model showed slow progression of lung tumours which has helped us to assess early indicators of oxidative damage in lungs by studying the levels of lipid peroxidation and antioxidant parameters. LPO was elevated by 46.94?%, SOD, CAT, GSH and GR activity was decreased by 48.67?%, 22.04?%, 21.46?% and 20.85?%, respectively in serum of NNK treated rats when compared with control. These findings suggest that increased oxidative stress can represent a risk factor for the development of chronic disease in early future. This new animal model is an attempt to greatly facilitate studies of the pathophysiology, biochemistry and therapy of lung cancer.