Efficient design, synthesis and structure–activity relationship studies of 1-(3-/em>-substituted propyl)-4-arylpiperidines as non-peptide antagonists of nociceptin/orphanin FQ receptor: biological activities, metabolic stabili

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• 作者：Shigeo Hayashi (1)
  Katsuyo Ohashi (1)
  Eriko Nakata (1)
  Chie Emoto (1)
  
• 关键词：Nociceptin/orphanin FQ (N/OFQ) ; NOP (ORL1) receptor selective antagonist ; Metabolic stability ; hERG potassium ion channel binding ; Prolong QT interval issues ; Multi ; viewpoint and integrated drug ; design strategies
• 刊名：Medicinal Chemistry Research
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：23
• 期：1
• 页码：526-552
• 全文大小：3,625 KB
• 作者单位：Shigeo Hayashi (1)
  Katsuyo Ohashi (1)
  Eriko Nakata (1)
  Chie Emoto (1)
  
  1. Nagoya Laboratories, Pfizer Global Research & Development, Pfizer Japan Inc., 5-2 Taketoyo, Aichi, 470-2393, Japan
  
• ISSN：1554-8120

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