Behavioral and endocrine changes following antisense oligonucleotide-induced reduction in the rat NOP receptor

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• 作者：GregoryG. Blakley ; LarissaA. Pohorecky and Daniel Benjamin
• 关键词：Orphanin FQ ; Nociception ; Opioid ; Antisense
• 刊名：Psychopharmacology
• 出版年：2004
• 出版时间：February 2004
• 年：2004
• 卷：171
• 期：4
• 页码：421-428
• 全文大小：314 KB

文摘

Rationale Compared with the use of classic receptor ligands, antisense oligonucleotides (ASO) targeted at specific central nervous system receptors are an effective alternative in experiments designed to examine the behavioral role of such systems.