Impact of Surgery on Quality of Life in Patients with Hepatocellular Carcinoma
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  • 作者:Yoshihiro Mise (1)
    Shouichi Satou (1)
    Takeaki Ishizawa (1)
    Junichi Kaneko (1)
    Taku Aoki (1)
    Kiyoshi Hasegawa (1)
    Yasuhiko Sugawara (1)
    Masatoshi Makuuchi (2)
    Norihiro Kokudo (1)
  • 刊名:World Journal of Surgery
  • 出版年:2014
  • 出版时间:April 2014
  • 年:2014
  • 卷:38
  • 期:4
  • 页码:958-967
  • 全文大小:2,945 KB
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  • 作者单位:Yoshihiro Mise (1)
    Shouichi Satou (1)
    Takeaki Ishizawa (1)
    Junichi Kaneko (1)
    Taku Aoki (1)
    Kiyoshi Hasegawa (1)
    Yasuhiko Sugawara (1)
    Masatoshi Makuuchi (2)
    Norihiro Kokudo (1)

    1. Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
    2. Department of Hepato-Biliary-Pancreatic Surgery, Japanese Red Cross Medical Center, Tokyo, Japan
  • ISSN:1432-2323
文摘
Background Liver resection is the mainstay of curative treatment for localized hepatocellular carcinoma (HCC). However, the impact of surgery for HCC on quality of life (QOL) has not been well assessed. Methods Health-related QOL was assessed using the Short Form-36 questionnaire in 108 patients who underwent a liver resection for HCC between January 2004 and January 2008. The QOL assessment was scheduled before and every 3?months after the operation. Patients were divided into two groups based on patient-, tumor-, and surgery-related variables. The physical component summary (PCS) and mental component summary (MCS) were compared between the two groups. Results Altogether, 69 patients (64?%) completed the consecutive QOL assessments until 6?months after surgery. At 3?months, the PCS scores were significantly lower for women and for patients who had undergone thoracotomy than among men (p?=?0.010) and patients who had not undergone thoracotomy (p?=?0.048), respectively. No significant differences in any of the PCS scores were observed at 6?months. No significant differences in the MCS scores were observed between the groups throughout the investigation, and improvement relative to the preoperative status was observed at 6?months. Conclusions Physical impairments in the QOL after surgery had returned to the baseline at 6?months, and the postoperative mental QOL improved relative to the preoperative state. The surgical candidates were expected to have a satisfactory QOL regardless of the preoperative status and surgical outcomes. A thoracoabdominal approach had a transient negative impact on the physical health status.

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