A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus

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• 作者：Satoshi Hiramine ; Masaya Sugiyama ; Norihiro Furusyo…
• 关键词：Genetic marker ; Microsatellite ; Interferon lambda 3
• 刊名：Journal of Gastroenterology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：50
• 期：10
• 页码：1069-1077
• 全文大小：536 KB
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• 作者单位：Satoshi Hiramine (1) (2)
  Masaya Sugiyama (1)
  Norihiro Furusyo (2)
  Hirofumi Uto (3)
  Akio Ido (3)
  Hirohito Tsubouchi (3)
  Hisayoshi Watanabe (4)
  Yoshiyuki Ueno (4)
  Masaaki Korenaga (1)
  Kazumoto Murata (1)
  Naohiko Masaki (1)
  Jun Hayashi (2)
  David L. Thomas (5)
  Masashi Mizokami (1)
  
  1. Department of Hepatic Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1-7-1 Kohonodi, Ichikawa, 272-8516, Chiba, Japan
  2. General Internal Medicine Department, Kyushu University Hospital, Fukuoka, 812-8582, Japan
  3. Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan
  4. Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan
  5. Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Oncology
  Surgical Oncology
  Hepatology
  Internal Medicine
  Colorectal Surgery
  
• 出版者：Springer Japan
• ISSN：1435-5922

文摘

Background Genome-wide association studies have revealed several single-nucleotide polymorphisms around interleukin 28B (IL28B) that are strongly associated with hepatitis C virus (HCV) clearance. However, their predictive value is not perfect, which suggests that other genetic factors may also be involved in HCV clearance. We previously reported a wide variation in the length of a thymine–adenine (TA) dinucleotide repeat in the promoter region of IL28B and that the transcriptional activity of the promoter increased gradually in a TA repeat length-dependent manner.