Effect of handrubbing using locally-manufactured alcohol-based handrubs in paediatric wards in Harare, Zimbabwe

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• 作者：Muchaneta Gudza-Mugabe ; Marcelyn T. Magwenzi…
• 关键词：Hand hygiene ; Contamination ; Gram negative bacteria ; Nosocomial infection ; Paediatric ; Alcohol ; based hand rub
• 刊名：Antimicrobial Resistance & Infection Control
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：6
• 期：1
• 全文大小：345KB
• 刊物主题：Medical Microbiology; Drug Resistance; Infectious Diseases;
• 出版者：BioMed Central
• ISSN：2047-2994
• 卷排序：6

文摘

We assessed bacterial contamination of hands of adults present in paediatric wards in two tertiary-care hospitals in Harare, Zimbabwe and the microbiologic efficacy of locally-manufactured alcohol-based hand rub (ABHR). During unannounced visits, samples were collected using hand-print and hand-rinse methods. Samples were collected from 152 individuals (16 nurses, 10 doctors, 28 students, 86 parents/guardians, 12 others). Contamination of hands with Gram-negative bacteria was found in 91% of adults tested with a mean of 14.6 CFU (hand-rinse method; IQR 3–65), representing a high risk for transmission of pathogens potentially leading to nosocomial infections. A single application of ABHR under controlled conditions achieved an average of 82% (or 0.72 log) reduction in detectable counts. Amongst 49 Enterobacteriaceae isolates from hands, 53% were resistant to gentamicin and 63% were resistant to cefpodoxime. Use of ABHR represents an attractive intervention for reducing nosocomial infections in this setting.