Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study
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- 作者：Jaroslav Flegr (1)
Ji?í Klose (2)
Martina Novotná (1)
Miroslava Berenreitterová (1)
Jan Havlí?ek (3) - 刊名：BMC Infectious Diseases
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：9
- 期：1
- 全文大小：660KB
- 参考文献：1. Tenter AM, Heckeroth AR, Weiss LM:Toxoplasma gondii : from animals to humans. / Int J Parasitol 2000, 30:1217-258. i.org/10.1016/S0020-7519(00)00124-7">CrossRef
2. Remington JS, Krahenbuhl JL: Immunology of Toxoplasma gondii . / Immunology of human infection, Part II / (Edited by: Nahmias AJ, O'Reilly J). New York: Plenum Publishing Corporation 1982, 327-71.
3. Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, Mcauley JB:Toxoplasma gondii infection in the United States: Seroprevalence and risk factors. / Am J Epidemiol 2001, 154:357-65. i.org/10.1093/aje/154.4.357">CrossRef
4. Markell EK, John DT, Krotoski WA: / Markell and Voge's Medical parasitology / 8 Edition Philadelphia: W.B. Saunders Company 1999.
5. Roberts LS, Janovy J Jr: / Roberts' Foundations of parasitology / 6 Edition / (Edited by: Gerald S Schmidt, Larry S). Boston: McGraw-Hill Companies, Inc 2000.
6. Havlí?ek J, Ga?ová Z, Smith AP, Zvára K, Flegr J: Decrease of psychomotor performance in subjects with latent 'asymptomatic' toxoplasmosis. / Parasitology 2001, 122:515-20.
7. Flegr J, Havlí?ek J, Kodym P, Maly M, Smahel Z: Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study. / BMC Infect Dis 2002., 2: art-11
8. Yereli K, Balcioglu IC, Ozbilgin A: -Is Toxoplasma gondii a potential risk for traffic accidents in Turkey? / Forensic Sci Int 2006, 163:34-7. i.org/10.1016/j.forsciint.2005.11.002">CrossRef
9. Novotná M, Havlí?ek J, Smith AP, Kolbeková P, Skallová A, Klose J, Ga?ová Z, Písa?ka M, Sechovská M, Flegr J:Toxoplasma and reaction time: Role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. / Parasitology 2008, 135:1253-261.
10. Flegr J, Novotná M, Lindová J, Havlí?ek J: Neurophysiological effect of Rh factor. Protective role of the RhD molecule against Toxoplasma -induced impairment of reaction times in women. / Neuro Endocrinol Lett 2008, 29:475-81.
11. Kustu S, Inwood W: Biological gas channels for NH 3 and CO 2 : evidence that Rh (rhesus) proteins are CO2 channels. / Transf Clin Biol 2006, 13:103-10. i.org/10.1016/j.tracli.2006.03.001">CrossRef
12. Biver S, Scohy S, Szpirer J, Szpirer C, Andre B, Marini AM: Physiological role of the putative ammonium transporter RhCG in the mouse. / Transf Clin Biol 2006, 13:167-68. i.org/10.1016/j.tracli.2006.03.003">CrossRef
13. Flegr J, Hrdy I: Influence of chronic toxoplasmosis on some human personality factors. / Folia Parasitol 1994, 41:122-26.
14. Daniels G: / Human blood groups Oxford: Blackwell Publishers 2002. i.org/10.1002/9780470987018">CrossRef
15. Kodym P, Maly M, Svandová E, Lekatková H, Badoutová M, Vlková J, Bene? C, Zástěra M:Toxoplasma in the Czech Republic 1923-999: first case to widespread outbreak. / Int J Parasitol 2000, 30:11-8.
16. Pokorny J, Fruhbauer Z, Polednakova S, Sykora J, Zastera M, Fialova D: Stanoveni antitoxoplasmickych protilatek IgG netodou ELISA (Assessment of antitoxoplasmatic IgG antibodies with the ELISA method). / Cs Epidem 1989, 38:355-61.
17. Kodym P, Machala L, Rohá?ová H, ?irocká B, Maly M: Evaluation of a commercial IgE ELISA in comparison with IgA and IgM ELISAs, IgG avidity assay and complement fixation for the diagnosis of acute toxoplasmosis. / Clin Microbiol Infect 2007, 13:40-7. i.org/10.1111/j.1469-0691.2006.01564.x">CrossRef
18. Montoya JG, Liesenfeld O: Toxoplasmosis. / Lancet 2004, 363:1965-975. i.org/10.1016/S0140-6736(04)16412-X">CrossRef
19. Petridou E, Moustaki M: Human factors in the causation of road traffic crashes. / Europ J Epidemiol 2000, 16:819-26. i.org/10.1023/A:1007649804201">CrossRef
20. Hrdá S, Votypka J, Kodym P, Flegr J: Transient nature of Toxoplasma gondii -induced behavioral changes in mice. / J Parasitol 2000, 86:657-63.
21. Flegr J, Hru?ková M, Hodny Z, Novotná M, Hanu?ová J: Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis. / Parasitology 2005, 130:621-28. i.org/10.1017/S0031182005007316">CrossRef
22. Hodková H, Kolbeková P, Skallová A, Lindová J, Flegr J: Higher perceived dominance in Toxoplasma infected men -the new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior. / Neuro Endocrinol Lett 2007,28(2):110-14.
23. Flegr J, Lindová J, Kodym P: Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans. / Parasitology 2008, 135:427-31. i.org/10.1017/S0031182007004064">CrossRef
24. Archer J: Testosterone and human aggression: an evaluation of the challenge hypothesis. / Neurosci Biobehav Rev 2006, 30:319-45. i.org/10.1016/j.neubiorev.2004.12.007">CrossRef
25. The pre-publication history for this paper can be accessed here:iomedcentral.com/1471-2334/9/72/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-2334/9/72/prepub - 作者单位：Jaroslav Flegr (1)
Ji?í Klose (2)
Martina Novotná (1)
Miroslava Berenreitterová (1)
Jan Havlí?ek (3)
1. Department of philosophy, Faculty of Science, Charles University, Vinièná 7, Prague, 128 44, Czech Republic
2. Central Medical Psychology Department, Central Military Hospital, U vojenské nemocnice 1200, Prague, 169 02, Czech Republic
3. Department of Anthropology, Faculty of Humanities, Charles University, Husnikova 2075, Prague, 158 00, Czech Republic
文摘
Background Latent toxoplasmosis, protozoan parasitosis with prevalence rates from 20 to 60% in most populations, is known to impair reaction times in infected subjects, which results, for example, in a higher risk of traffic accidents in subjects with this life-long infection. Two recent studies have reported that RhD-positive subjects, especially RhD heterozygotes, are protected against latent toxoplasmosis-induced impairment of reaction times. In the present study we searched for increased incidence of traffic accidents and for protective effect of RhD positivity in 3890 military drivers. Methods Male draftees who attended the Central Military Hospital in Prague for regular entrance psychological examinations between 2000 and 2003 were tested for Toxoplasma infection and RhD phenotype at the beginning of their 1 to1.5-year compulsory military service. Subsequently, the data on Toxoplasma infection and RhD phenotype were matched with those on traffic accidents from military police records and the effects of RhD phenotype and Toxoplasma infection on probability of traffic accident was estimated with logistic regression. Results We confirmed, using for the first time a prospective cohort study design, increased risk of traffic accidents in Toxoplasma-infected subjects and demonstrated a strong protective effect of RhD positivity against the risk of traffic accidents posed by latent toxoplasmosis. Our results show that RhD-negative subjects with high titers of anti-Toxoplasma antibodies had a probability of a traffic accident of about 16.7%, i.e. a more than six times higher rate than Toxoplasma-free or RhD-positive subjects. Conclusion Our results showed that a common infection by Toxoplasma gondii could have strong impact on the probability of traffic accident in RhD negative subjects. The observed effects could provide not only a clue to the long-standing evolutionary enigma of the origin of RhD polymorphism in humans (the effect of balancing selection), but might also be the missing piece in the puzzle of the physiological function of the RhD molecule.