HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway

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• 作者：Shengjie Dai ; Jie Zhang ; Shihao Huang ; Bin Lou ; Binbo Fang…
• 关键词：Epithelial–mesenchymal transition ; HNRNPA2B1 ; ERK/snail ; Pancreatic cancer
• 刊名：Cancer Cell International
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：7373KB
• 刊物主题：Cancer Research; Cell Biology;
• 出版者：BioMed Central
• ISSN：1475-2867
• 卷排序：17

文摘

BackgroundHeterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition and invasion and metastasis capacities. However, its function in the epithelial–mesenchymal transition (EMT) of pancreatic cancer is not fully understood.