A facile ZrO₂ nanoparticles catalyzed synthesis of 2-amino-5-arylpyrimido[4,5-b]quinolinediones

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• 作者：Manouchehr Mamaghani ; Mona Jamali Moghadam…
• 关键词：Nanocatalyst ; ZrO2 (NPs) ; Multicomponent ; Pyrimido[4 ; 5 ; b]quinoline ; 2 ; 6 ; diaminopyrimidin ; 4(1H) ; one
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 页码：395-401
• 全文大小：
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428
• 卷排序：14

文摘

In this investigation, an efficient and ecofriendly multicomponent reaction is described for the green synthesis of 2-amino-5-arylpyrimido[4,5-b]quinolinedione derivatives using ZrO₂ (NPs). In this protocol, the reaction of 2,6-diaminopyrimidin-4(1H)-one, arylaldehyde and 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione in the presence of ZrO₂ (NPs) in ethylene glycol at 120 °C produced the desired products in excellent yields (90–98 %) and short reaction times (8–60 min.). Use of recyclable catalyst, green solvent, easy workup and excellent yields are the notable features of this method.