Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs
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- 作者：S. Chen ; J. Zhao ; L. Cui ; Y. Liu
- 关键词：NSCLC ; Cell free DNA ; TKI treatment ; Drug resistance ; Liquid biopsy ; EGFR mutations
- 刊名：Clinical and Translational Oncology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：19
- 期：3
- 页码：332-340
- 全文大小：
- 刊物主题：Oncology;
- 出版者：Springer International Publishing
- ISSN：1699-3055
- 卷排序：19
文摘
PurposeChanges in EGFR profiles of non small cell lung cancer (NSCLC) patients correlates to clinical outcome. Extracting quality tumor tissue remains a challenge for molecular profiling. Our study aims to ascertain the clinical relevance of urinary cell free DNA as an alternative tumor material source.