Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2

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• 作者：Feng Cai ; Qingqing Zhu ; Yingying Miao…
• 关键词：NSCLC ; Desmoglein ; 2 ; Tumor cell proliferation ; Cell cycle regulation
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：143
• 期：1
• 页码：59-69
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

PurposeDesmoglein-2 (Dsg2) is a cell adhesion protein of the cadherin superfamily. Altered Dsg2 expression is associated with tumorigenesis. This study determined Dsg2 expression in non-small cell lung cancer (NSCLC) tissue specimens for association with clinicopathological and survival data and then assessed the effect of Dsg2 knockdown on regulation of NSCLC cell malignant behaviors in vitro and in nude mouse xenografts.