The role of microRNAs in resistance to targeted treatments of non-small cell lung cancer
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- 作者：Hongjing Zang ; Weiyuan Wang ; Songqing Fan
- 关键词：MicroRNAs ; Targeted treatment ; Drug resistance ; NSCLC ; EGFR
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：79
- 期：2
- 页码：227-231
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Oncology; Pharmacology/Toxicology; Cancer Research;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0843
- 卷排序：79
文摘
PurposeNon-small cell lung cancer (NSCLC), accounting for the most of lung cancers, is usually diagnosed in advanced stage. Targeted treatments boost advanced NSCLC patients with certain mutations, but early drug resistance blocks the advantages of target medicine. MicroRNAs (miRNAs) are regarded as a cluster of small noncoding and posttranscriptionally negative regulating RNAs. We want to explore the role of miRNAs in resistance to targeted treatments of NSCLC to improve the prognosis.