Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote
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- 作者：Creus ; N. ; Mateu ; J. ; Massó ; J. ; Codina ; C. ; Ribas ; J.
- 关键词：Antidote ; DMSO ; Extravasation ; Stem ; cell transplants
- 刊名：Pharmacy World Science
- 出版年：2002
- 出版时间：2002
- 年：2002
- 卷：24
- 期：5
- 页码：175-176
- 全文大小：48 KB
文摘
DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed..