Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA)

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• 作者：Roman Romero-Ortuno ; Matthew D. L. O’Connell…
• 关键词：Finometer? ; Orthostatic hypotension ; Hemodynamics ; Heart rate ; Mortality ; Longitudinal studies
• 刊名：Aging Clinical and Experimental Research
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：27
• 期：2
• 页码：239-242
• 全文大小：270 KB
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• 刊物主题：Geriatrics/Gerontology;
• 出版者：Springer International Publishing
• ISSN：1720-8319

文摘

Background Orthostatic hemodynamic signals may predict adverse outcomes in elders. Aims To study the association between orthostatic hemodynamics and incident mortality in The Irish Longitudinal Study on Ageing (TILDA). Methods Wave 1 subjects underwent an active stand with non-invasive beat-to-beat blood pressure monitoring. We compared wave 1 active stands, dead vs alive in wave 2. Results Compared to the 4,415 participants who had not died, the 53 who had died had a higher baseline heart rate [HR mean of 69 vs 65 beats per minute (bpm)] and a higher mean orthostatic HR, especially between 30 and 60?s post-stand (mean of 79 vs 73?bpm). After adjusting for age, sex, baseline HR, mini-mental state examination score and cardiovascular comorbidities and medications, the mean HR between 30 and 60?s post-stand independently predicted mortality (baseline HR did not). Discussion Higher early orthostatic HR may be an independent risk marker. Further validation is required.