Octreotide and Lanreotide in Gastroenteropancreatic Neuroendocrine Tumors
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  • 作者：Venkata K. Pokuri ; Mei Ka Fong ; Renuka Iyer
  • 关键词：Octreotide ; Lanreotide ; Synthetic ; Somatostatin ; Gastroenteropancreatic ; Neuroendocrine tumors ; Cost ; analysis
  • 刊名：Current Oncology Reports
  • 出版年：2016
  • 出版时间：January 2016
  • 年：2016
  • 卷：18
  • 期：1
  • 全文大小：310 KB
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  • 作者单位：Venkata K. Pokuri (1)
    Mei Ka Fong (2)
    Renuka Iyer (1)

    1. Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA
    2. Department of Pharmacy, Carolinas Healthcare System, Levine Cancer Institute, Charlotte, NC, USA
  • 刊物主题：Oncology;
  • 出版者：Springer US
  • ISSN：1534-6269
    • 文摘
    Neuroendocrine tumors are heterogeneous, rare malignancies that arise most commonly in the gastrointestinal tract and pancreas. They often secrete vasoactive substances resulting in carcinoid syndrome and the tumor cells exclusively express somatostatin receptors. Octreotide and lanreotide are the two synthetic somatostatin analogs used for the control of carcinoid symptoms and tumor progression in advanced inoperable disease. Recent pivotal trials (PROMID and CLARINET studies) established their antitumor activity. We discuss the available data to support their use as symptom controlling and antiproliferative agents. This article also reviews the guidelines (National Comprehensive Cancer Network and North American Neuro Endocrine Tumor Society), cost-analysis (suggesting the cost-effectiveness of lanreotide autogel compared to higher doses of octreotide long acting release formulation in refractory patients), and future directions of somatostatin analogs in the management of patients refractory to conventional doses of octreotide and lanreotide. Keywords Octreotide Lanreotide Synthetic Somatostatin Gastroenteropancreatic Neuroendocrine tumors Cost-analysis

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